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TranscriptomicsExpression of miRNA from lung tissue from Systemic Sclerosis patients with interstitial lung disease (SSc-ILD) and healthy controls.
Objective: MicroRNAs (miRNAs) control key elements of mRNA stability and likely contribute to the dysregulated lung gene expression observed in systemic sclerosis associated interstitial lung disease (SSc-ILD). We analyzed the miRNA gene expression of tissue and cells from SSc-ILD patients. A chroni...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-81293 | biostudies-arrayexpress
TranscriptomicsExpression of mRNA from lung tissue from Systemic Sclerosis patients with interstitial lung disease (SSc-ILD) and healthy controls (HC)
Objective: MicroRNAs (miRNAs) control key elements of mRNA stability and likely contribute to the dysregulated lung gene expression observed in systemic sclerosis associated interstitial lung disease (SSc-ILD). We analyzed the miRNA gene expression of tissue and cells from SSc-ILD patients. A chroni...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-81292 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression of adult rat retinas exposed to light.
We performed a microarray screening of adult rat retinas to identify genes that could show and up- or down-regulation due to exposure to light. This study was performed using ex-vivo retinas collected from adult Long Evans rats that were exposed to light (1000 Lux), or were left in dark as control. ...
ORGANISM(S): Rattus norvegicus 
2011-10-29 | E-GEOD-29299 | biostudies-arrayexpress
TranscriptomicsMicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation
We compared the aorta of 6-weeks-old mice (young) with 18-months-old mice (old). Using the publicly available tools Sylamer and DIANA-mirExTra, we identified an enrichment for miR-29 binding sites in the 3'UTR of genes downregulated in the aged aortas. We subsequently showed that inhibition of miR-2...
ORGANISM(S): Mus musculus 
2011-10-13 | E-GEOD-32937 | biostudies-arrayexpress
TranscriptomicsINDUCTION OF PANCREATIC ISLET CELL DIFFERENTIATION BY THE NEUROGENIN-NEUROD CASCADE
Neurog3 and NeuroD1 share the ability to induce endocrine differentiation when expressed ectopically in vivo (Apelqvist et al., 1999; Schwitzgebel et al., 2000; Grapin-Botton et al., 2001) and in vitro (Heremans et al., 2002; Gasa et al., 2004), suggesting that they target a common set of genes. To...
ORGANISM(S): Mus musculus 
2007-08-29 | E-GEOD-7884 | biostudies-arrayexpress
TranscriptomicsEffect of High Fat Diet on gene expression of liver from obesity-prone (C57BL/6J) and obesity-resistant (A/J) mice
Mice were fed for 2, 10 or 30 days with a normal chow (NC) or a high fat diet (HFD). At each time point, mice were sacrificed and liver samples were collected and immediately frozen in liquid nitrogen. Total RNA from each sample was further extracted, purified, quality-controled before and after amp...
ORGANISM(S): Mus musculus 
2009-08-09 | E-GEOD-12409 | biostudies-arrayexpress
TranscriptomicsThe amniotic fluid transcriptome: a source of novel information about human fetal development
Amniotic fluid (AF) is a complex biological material that provides a unique window into the developing human. Residual AF supernatant contains cell-free fetal RNA. The objective of this study was to develop an understanding of the AF core transcriptome by identifying the transcripts ubiquitously pre...
ORGANISM(S): Homo sapiens 
2012-01-11 | E-GEOD-33168 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human tetraploid and polyploid (8N and 16N) megakaryocytes to identify genes which are up and down regulated during megakaryocyte differentiation/polyploidization
The aim of the experiment was to characterize by a pan-genomic approach genes which are continuously up and down regulated during polyploidization during megakaryocyte differentiation.
ORGANISM(S): Homo sapiens 
2007-04-16 | E-TABM-133 | biostudies-arrayexpress
TranscriptomicsGene Expression Profile for the identification of miR-126 targets
"The analysis was designed to search for putative seed sequences for miR-126 in the 3M-bM-^@M-^YUTR of up-regulated genes. ECs were co-transfected with anti-miR-126 and a plasmid vector bearing the GFP-coding sequence and three complementary sites for miR-126 downstream. As a consequence of the...
ORGANISM(S): Homo sapiens 
2013-10-18 | E-GEOD-32089 | biostudies-arrayexpress
TranscriptomicsGeneration of transcriptome catalogs for global analysis of gene expression in non-model organisms
We have developed a method based on 454 sequencing of 3â?? cDNA fragments from a normalized library constructed from pooled RNAs to generate, through de novo reads assembly, a large catalog of unique transcripts in organisms for which a comprehensive collection of transcripts or the complete genome ...
ORGANISM(S): Vitis vinifera 
2010-06-25 | E-GEOD-14276 | biostudies-arrayexpress
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