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TranscriptomicsKnock-down of the methyltransferase Kmt6 reliefs H3K27me3 and induces expression of cryptic otherwise silent secondary metabolite gene clusters in Fusarium fujikuroi [gene expression]
Filamentous fungi produce a vast array of secondary metabolites (SMs) and some of them are applied in agriculture or pharmacology. Recent sequencing of the rice pathogen Fusarium fujikuroi revealed the presence of far more SM-encoding genes than known products. SM production is energy-consuming and ...
ORGANISM(S): Fusarium fujikuroi 
2016-07-04 | E-GEOD-80477 | biostudies-arrayexpress
GenomicsGenome-wide mapping of 5-hydroxymethylcytosine (5hmC) during differentiation of P19.6 and 3T3-L1 cells
Enhancers are developmentally-controlled transcriptional regulatory regions whose activities are modulated through histone modifications or histone variant deposition. Here, we show by genome-wide mapping that the newly discovered DNA modification 5-hydroxymethylcytosine (5hmC) is dynamically associ...
ORGANISM(S): Mus musculus 
2012-06-04 | E-GEOD-38407 | biostudies-arrayexpress
UnknownInvestigation of urban birds as source of β-lactamase-producing Gram-negative bacteria in Marseille city, France.
Not available
S-EPMC6822345 | biostudies-literature
TranscriptomicsIdentification of new genes involved in human adipogenesis and fat storage
Since the worldwide increase in obesity represents a growing challenge for the health care systems, new approaches are needed to treat obesity and associated disease effectively. The food intake is primarily stored in the adipose tissue and therefore this organ is in focus to develop new anti-obesit...
ORGANISM(S): Homo sapiens 
2012-03-06 | E-GEOD-28628 | biostudies-arrayexpress
UnknownEmergence of Methicillin-Resistant Staphylococcus aureus ST239/241 SCCmec-III Mercury in Eastern Algeria.
Not available
S-EPMC8621676 | biostudies-literature
UnknownfosM, a New Family of Fosfomycin Resistance Genes Identified in Bacterial Species Isolated from Human Microbiota.
Not available
S-EPMC7848996 | biostudies-literature
UnknownTemperate Prophages Increase Bacterial Adhesin Expression and Virulence in an Experimental Model of Endocarditis Due to Staphylococcus aureus From the CC398 Lineage.
Not available
S-EPMC6492496 | biostudies-literature
TranscriptomicsControl of Reproductive Floral Organ Identity Specification in Arabidopsis by the C Function Regulator AGAMOUS (expression)
Characterization of the activities of the transcription factor that AG encodes throughout flower development using perturbation assays in combination with a floral induction system (FIS) that allows a stage-specific analysis of flower development. The series contains static perturbation experiments ...
ORGANISM(S): Arabidopsis thaliana 
2013-07-01 | E-GEOD-44919 | biostudies-arrayexpress
TranscriptomicsDe novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function
Background: Despite significant improvements in short-term kidney transplant survival, comparable increases in 5 and 10-year outcomes have not been achieved. Chronic allograft nephropathy (CAN) is a major cause of late graft loss. Toxic nephropathy and inadequate long-term immunosuppression are poss...
ORGANISM(S): Homo sapiens 
2004-09-23 | E-GEOD-1743 | biostudies-arrayexpress
TranscriptomicsMicroarray gene profiling in glucocorticoid-induced Avascular Necrosis of the Femoral Head in a Rat Model
Wistar Kyoto Rats were administered glucocorticoid pellets and placebo pellets for 6 months. After 6 months rats were sacrificed and their femoral heads were histologically examined for the detection of avascular necrosis of the femoral head. Total RNA was extracted from femoral heads and submitted ...
ORGANISM(S): Rattus norvegicus 
2011-06-09 | E-MEXP-2751 | biostudies-arrayexpress
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