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MetabolomicsLimited oxygen availability in standard cell culture alters metabolism and function in terminally differentiated cells

Cell culture is generally considered to be hyperoxic. However, the importance of cellular oxygen consumption is often underappreciated, with rates of oxygen consumption often sufficient to cause hypoxia at cell monolayers. We initially focused on cultured adipocytes as a terminally differentiated...

2024-02-21 | MTBLS6677 | MetaboLights
MetabolomicsUntargeted LC-MS metabolomics of RANKL-differentiated Bone Marrow–Derived Macrophages ± Bacillus Calmette–Guérin (BCG) exposure

To investigate the metabolites and pathways modulated by BCG in RANKL-differentiated macrophages, thereby elucidating the metabolic mechanisms underlying BCG-induced macrophage activation, BMMs were stimulated with 50 ng/mL RANKL for 5 days to generate osteoclast-like cells. Subsequently, one gro...

2026-03-31 | MTBLS12992 | MetaboLights
MetabolomicsTimecourse on primary human highly differentiated airway epithelial cells infected with HRV-C15
Not available
ORGANISM(S): Homo sapiens 
ST001774 | MetabolomicsWorkbench
MetabolomicsIntegrated transcriptomic and metabolomic analysis reveals the metabolic programming of GM-CSF-and M-CSF-differentiated mouse macrophages

Macrophages play a critical role in the inflammatory response and tumor development. Macrophages are primarily divided into pro-inflammatory M1-like and anti-inflammatory M2-like macrophages based on their activation status and functions. In vitro macrophage models could be derived from ...

2023-09-19 | MTBLS6502 | MetaboLights
MetabolomicsGut-Muscle Axis Regulates Meat Quality in Lambs: Rumen Microbiota-Differentiated L-Arginine and Serotonin Signaling Mediates Muscle Lipid Remodeling

This study investigated age-associated changes in the gut-muscle axis and their potential contribution to meat quality in Tan sheep (Ovis aries). Twelve Tan sheep were divided into two age groups, including six 3-month-old animals (T3) and six 6-month-old animals (T6). Untargeted LC-MS metabolomi...

2026-09-03 | MTBLS15419 | MetaboLights
GenomicsGenomic profiling of matched well differentiated and de-differentiated liposarcoma.
Well-differentiated (WD) and de-differentiated (DD) liposarcoma, subtypes of adipocytic sarcomas, are pathologically and clinically dissimilar, but are poorly distinguishable at the molecular level. These tumors harbor neochromosomes formed from amplifications and rearrangements of chr12q. Nineteen ...
EGAS00001002807 | EGA
TranscriptomicsGene expression profiling associated with the progression to poorly differentiated thyroid carcinomas
Poorly differentiated thyroid carcinomas (PDTC) represent a heterogeneous, aggressive entity, presenting features that suggest a progression from well-differentiated carcinomas. To elucidate the mechanisms underlying such progression and identify novel therapeutical targets, we assessed the genome-w...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-53157 | biostudies-arrayexpress
GenomicsSmall RNA profiling of differentiated and de-differentiated vascular smooth muscle cell
Small RNA profiling of differentiated and de-differentiated vascular smooth muscle cell
PRJNA777063 | ENA
ProteomicsProteomic analysis of radioiodine-refractory differentiated thyroid cancer
Radioiodine refractory differentiated thyroid cancer (RR-DTC) is the main factor affecting the overall survival rate of thyroid cancer clinically. In order to investigate its underlying molecular mechanism of pathogenesis with the hope to explore novel therapeutic targets for clinical treatment, we ...
ORGANISM(S): Homo Sapiens 
2022-11-05 | PXD037968 |
GenomicsTrap1 differentiated 3T3-L1 cells
Trap1 differentiated 3T3-L1 cells
PRJEB85703 | ENA
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