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MetabolomicsA polyamine-centric blood-based metabolite panel predictive of poor response to CAR T-cell therapy in large B cell lymphoma

Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory (r/r) large B-cell lymphoma (LBCL) results in durable response in only a subset of patients. MYC overexpression in LBCL tumors is associated with poor response to treatment. We tested whether a MYC-driven polyamin...

2022-10-31 | MTBLS5381 | MetaboLights
MetabolomicsMetabonomics uncovers a reversible proatherogenic lipid profile during infliximab therapy of inflammatory bowel disease

BACKGROUND: One-third of inflammatory bowel disease (IBD) patients show no response to infliximab (IFX) induction therapy, and approximately half of patients responding become unresponsive over time. Thus, identification of potential treatment response biomarkers are of great cl...

2022-01-13 | MTBLS239 | MetaboLights
ProteomicsNovel epigenetic based differentiation therapy for Acute Myeloid Leukemia
We have identified and characterized two lysine (K) deacetylase inhibitors (DACi), CM-444 and CM-1758. These inhibitors demonstrate the ability to promote myeloid differentiation in all acute myeloid leukemia (AML) subtypes at low, non-cytotoxic doses, setting them apart from other commercially avai...
ORGANISM(S): Homo sapiens (Human) 
2024-06-03 | PXD050623 | Pride
Acetylome Bromodomains Daci Epigenetics Non-histone proteins acetylation Acute myeloid leukemia Differentiation-based therapy 
GenomicsNovel epigenetic based differentiation therapy for Acute Myeloid Leukemia
Novel epigenetic based differentiation therapy for Acute Myeloid Leukemia
PRJNA1114031 | ENA
GenomicsNovel epigenetic based differentiation therapy for Acute Myeloid Leukemia
Novel epigenetic based differentiation therapy for Acute Myeloid Leukemia
PRJNA907770 | ENA
TranscriptomicsNovel epigenetic based differentiation therapy for Acute Myeloid Leukemia
Despite the development of novel therapies for acute myeloid leukemia (AML), outcomes remain poor for most patients, and therapeutic improvements are an urgent unmet need. Although treatment regimens promoting differentiation have succeeded in the treatment of acute promyelocytic leukemia (APL), the...
ORGANISM(S): Homo sapiens 
2024-05-20 | GSE219230 | GEO
GenomicsNovel epigenetic based differentiation therapy for Acute Myeloid Leukemia
Despite the development of novel therapies for acute myeloid leukemia (AML), outcomes remain poor for most patients, and therapeutic improvements are an urgent unmet need. Although treatment regimens promoting differentiation have succeeded in the treatment of acute promyelocytic leukemia (APL), the...
ORGANISM(S): Homo sapiens 
2024-05-21 | GSE268008 | GEO
UnknownEpigenetic-based differentiation therapy for Acute Myeloid Leukemia.
Not available
S-EPMC11219871 | biostudies-literature
TranscriptomicsA Chondrogenic Molecule that Repairs Cartilage by Transcriptional Regulation of CBF-beta
Osteoarthritis (OA) is a degenerative joint disease that involves destruction of articular cartilage and eventually leads to disability. Mesenchymal stem cells (MSCs) reside in healthy and diseased cartilage, and through their chondrogenic potential may provide a strategy for cartilage repair. To th...
ORGANISM(S): Homo sapiens 
2012-05-01 | E-GEOD-35546 | biostudies-arrayexpress
GenomicsNext Generation Sequencing-based on mRNA sequencing of human adipose mesenchymal stem cells submitted to osteogenic differentiation
Next Generation Sequencing-based on mRNA sequencing of human adipose mesenchymal stem cells submitted to osteogenic differentiation
PRJNA667749 | ENA
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