Sort   by:  
 Page size 
TranscriptomicsChromosomal aberration of asbestos-induced malignant mesothelioma in rats
Exposure to asbestos is a risk for malignant mesothelioma in humans. We carried out array comparative genomic hybridization (CGH) analysis in a rat model by repeated intraperitoneal injections of three types of asbestos including chrysotile, crocidolite and amosite. We found a common chromosomal del...
ORGANISM(S): Rattus norvegicus 
2012-08-13 | E-GEOD-36577 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling of Malignant Peritoneal Mesothelioma Patient Tumor Samples
Gene expression profiles were generated from 41 consecutive surgically resected fresh frozen malignant peritoneal mesothelioma patient tumor samples to identify molecular prognostic factors. Patient tumor samples hybridized against the common reference (complementary DNA generated from human univers...
ORGANISM(S): Homo sapiens 
2010-09-27 | E-GEOD-15627 | biostudies-arrayexpress
ProteomicsSpectral histopathology supported laser capture microdissection and quantitative proteome analysis of diffuse malignant mesothelioma
FTIR based spectral histopathology was used for label-free classification of tumor tissue sections. The regions of interest were identified and annotated with high spatial resolution. The spatial information was used for automated laser capture microdissection of relevant tissue areas. Subsequently,...
ORGANISM(S): Homo sapiens (Human) 
2017-03-31 | PXD004818 | Pride
Diffuse malignant mesothelioma Ftir Colorectal carcinoma Laser capture microdissection Infrared spectral histopathology 
TranscriptomicsGene expression changes between primary mesothelioma tumour cells and commercially available cell lines, compared to normal primary mesothelial cells
Malignant mesothelioma (MM) is an aggressive, fatal tumour strongly associated with asbestos exposure. There is an urgent need to improve MM patient outcomes and this requires functionally validated pre-clinical models. Mesothelioma-derived cell lines provide an essential and robust tool widely used...
ORGANISM(S): Homo sapiens 
2018-02-01 | E-MTAB-6351 | biostudies-arrayexpress
TranscriptomicsExpression data generated by syndecan-1 silencing in malignant mesothelioma STAV-AB cell line
The transcriptomic responses of syndecan-1 silencing in a human mesothelioma cell line was followed with microarray analysis. To project the transcriptome analysis on the full-dimensional picture of cellular regulation, we applied a novel method of network enrichment analysis which elucidated signal...
ORGANISM(S): Homo sapiens 
2012-11-01 | E-GEOD-37843 | biostudies-arrayexpress
GenomicsGene expression profiling of diffuse malignant peritoneal mesothelioma
Gene expression profiling of diffuse malignant peritoneal mesothelioma
PRJNA439682 | ENA
TranscriptomicsHuman Mesothelioma MicroRNA Study Part 1
MicroRNA expression profiles of malignant pleural mesothelioma (MPM) specimens were analyzed to identify novel microRNA that are potentially involved in the oncogenic transformation of human pleural cells. In addition to several novel MPM-associated microRNAs, we observed that the expression level ...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-40345 | biostudies-arrayexpress
TranscriptomicsMesothelioma tumor aCGH profiles
Malignant pleural mesotheliomas (MPMs) often show CDKN2A and NF2 inactivation but other highly recurrent mutations have not been described. To identify additional driver genes, we used an integrated genomic analysis of 53 MPM tumor samples to guide a focused sequencing effort that uncovered somatic ...
ORGANISM(S): Homo sapiens 
2011-09-25 | E-GEOD-29902 | biostudies-arrayexpress
TranscriptomicsAffymetrix microarray for gene expression patterns influenced by syndecan-1 overexpression in malignant mesothelioma STAV-AB cells
We aimed to investigate the function of syndecan-1 in tumor cell adhesion and migration, with special focus on the importance of its distinct protein domains, to better understand the structure-function relationship of syndecan-1 in tumor progression. We utilized two mesenchymal tumor cell lines whi...
ORGANISM(S): Homo sapiens 
2010-07-20 | E-GEOD-21401 | biostudies-arrayexpress
TranscriptomicsExpression data from mesothelial (LP9) and mesothelioma cells (HMESO) inhibited for extracellular-regulated kinase (ERK) 1, 2, or 5
Extracellular-regulated kinases (ERK1/2 and 5) are known to play important roles in growth and drug resistance of various cancers. Here we show roles of inhibition of ERK1, ERK2, or ERK5 on gene expression profiles of epithelioid malignant mesothelioma (MM) cells (HMESO). Untransfected human mesothe...
ORGANISM(S): Homo sapiens 
2010-05-08 | E-GEOD-21750 | biostudies-arrayexpress
Sort   by:  
 Page size