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ProteomicsDimeric IgA specifically disables intracellular mutated oncodrivers
Despite their long half-life, therapeutic antibodies are considered ineffective against intracellular antigens due to their perceived inability to penetrate epithelial cells. Using recombinant antibodies targeting common mutations in oncogenes, we show that dimeric IgA, but not the same antibody on ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD042914 | Pride
Transcytosis Cancer Therapeutic antibodies Immunoglobulin a 
ProteomicsNorovirus serum IgG and IgA repertoire
Dissecting the Clonal Composition and Determinants of Neutralization Potency Enhancement of Circulating Dimeric and Monomeric IgA to Human Norovirus
ORGANISM(S): Homo sapiens (Human) 
2026-07-09 | PXD066704 | Pride
Norovirus Antibody repertoire Igg Iga Serum proteomics 
ProteomicsDimeric IgA specifically disables intracellular mutated oncodrivers
Despite their long half-life, therapeutic antibodies are considered ineffective against intracellular antigens due to their perceived inability to penetrate epithelial cells. Using recombinant antibodies targeting common mutations in oncogenes, we demonstrate that dimeric IgA, but not the same antib...
ORGANISM(S): Homo Sapiens 
PXD044426 | panorama
GenomicsNext-Generation Sequencing of sgRNA spacer sequences from a CRISPRi library screen of the Salmonella enterica serovar Typhimurium 14028s genome in response to repeated monoclonal IgA treatment
For this study, we implemented the anti-lipopolysaccharide monoclonal IgA Sal4 in a genome-wide CRISPR interference (CRISPRi) screen to identify genes that modulate the extent of agglutination of Salmonella enterica serovar Typhimurium (STm) in response to antibody exposure. We leveraged our recentl...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2025-02-16 | E-MTAB-14834 | biostudies-arrayexpress
ProteomicsColonic spatial single-cell proteomics and murine models link mitochondrial dysfunction to dimeric IgA-secreting plasma cell deficiency in Crohn's disease
Secretory IgA (SIgA) is critical for maintaining the intestinal barrier. A dysregulated B-cell compartment and altered Ig secretion have been well documented in Crohn’s disease (CD) patients, although their origin is unknown. To unravel the role of mucosal humoral immunity in CD pathogenesis, we in-...
ORGANISM(S): Homo sapiens (Human) 
2026-01-13 | PXD069842 | Pride
ProteomicsInfluenza serum mIgA and dIgA repertoire on day 29 following seasonal influenza vaccination
Proteomic deconvolution of serum mIgA and dIgA repertoire specific to influenza HA following vaccination
ORGANISM(S): Homo sapiens (Human) 
2026-07-09 | PXD070307 | Pride
Influenza Monomeric iga Dimeric iga Antibodies 
GenomicsKrüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses
Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses
PRJNA674318 | ENA
UnknownEfficient Expression and Purification of Recombinant Mouse Dimeric IgA.
Not available
S-EPMC12435132 | biostudies-literature
UnknownBreast milk delivery of an engineered dimeric IgA protects neonates against rotavirus.
Not available
S-EPMC11982437 | biostudies-literature
UnknownSystemic administration of an HIV-1 broadly neutralizing dimeric IgA yields mucosal secretory IgA and virus neutralization.
Not available
S-EPMC5063654 | biostudies-literature
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