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UnknownEMG1 is essential for mouse pre-implantation embryo development.
Not available
S-EPMC2954994 | biostudies-literature
UnknownAkt inhibitor MK2206 selectively targets CLL B-cell receptor induced cytokines, mobilizes lymphocytes and synergizes with bendamustine to induce CLL apoptosis.
Not available
S-EPMC3975807 | biostudies-literature
UnknownOutcomes of a large cohort of individuals with clinically ascertained high-count monoclonal B-cell lymphocytosis.
Not available
S-EPMC6058787 | biostudies-literature
UnknownIdentifying weak interdomain interactions that stabilize the supertertiary structure of the N-terminal tandem PDZ domains of PSD-95.
Not available
S-EPMC6137104 | biostudies-literature
UnknownAkt inhibitor MK-2206 in combination with bendamustine and rituximab in relapsed or refractory chronic lymphocytic leukemia: Results from the N1087 alliance study.
Not available
S-EPMC5507724 | biostudies-literature
ProteomicsGlobal profiling of AMG510 modified proteins identified tumor suppressor KEAP1 as an off-target
Here, we presented a streamlined workflow to measure abundant AMG510 modified peptides including that of KRAS/G12C by direct profiling, and a pan-AMG510 antibody peptide IP workflow to profile less abundant AMG510 off-targets.
ORGANISM(S): Homo Sapiens 
2023-01-11 | PXD029449 |
UnknownBreaking the reproducibility barrier with standardized protocols for plant-microbiome research.
Not available
S-EPMC12416739 | biostudies-literature
ProteomicsPlasma proteome profiling combined with clinical and genetic features reveals pathophysiological characteristics of β-thalassemia
The phenotype of β-thalassemia underlies multigene interactions, making clinical stratification complicated. An increasing number of genetic modifiers affecting the disease severity have been identified, but are still unable to meet the demand of precision diagnosis. Here, we systematically conducte...
ORGANISM(S): Homo Sapiens 
2022-03-10 | PXD032179 |
Proteomicsβ-thalassemia plasma EVs proteomics
Here, we performed plasma extracellular vesicles (EVs) proteomics on 20 β-thalassemia major (TM) patients, 20 intermedia (TI) patients, and 20 healthy controls to explore the subgroup characteristics and the potential biomarkers. The proteome of paired plasma was analyzed in parallel to compare the ...
ORGANISM(S): Homo Sapiens 
2022-06-15 | PXD034548 |
ProteomicsDisrupting metformin adaptation of hepatocellular carcinoma by targeting TOMM34/ATP5B axis
As a well-known anti-diabetic drug, metformin has been repurposed for cancer treatment, but drug resistance and tumor metastasis observed recently have challenged its further application. Here, we found that long-term metformin exposure led to metabolic adaptation of HCC cells, which was characteriz...
ORGANISM(S): Homo Sapiens 
2022-07-14 | PXD035365 |
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