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Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease characterized by joint inflammation, systemic manifestations, and a heterogeneous clinical course marked by periods of remission and disease flares. The introduction of biologic therapies has revolutionized RA treatment by e...
ORGANISM(S): Homo sapiens (Human) 
2026-10-05 | PXD073940 | Pride
To test the contribution of distinct ST-DC populations to either autoimmunity and inflammation or sustained disease remission, we evaluated the phenotypes of their blood precursors in a human model of disease flare following treatment withdrawal in RA patients in disease remission (the BioRRA study,...
ORGANISM(S): Homo sapiens 
The purpose of the experiment was to compare the transcriptional profile of lupus nephritis kidney tissue at a first flare and expression at a repeated lupus nephritis episode. All samples were laser microdissected into glomerular and tubular compartments and samples were ran in different cartridges...
ORGANISM(S): Homo sapiens 
scRNAseq of PBMCs from idiopathic multicentric Castleman Disease (iMCD) flare and remission
Immune transcriptome in adult-onset Still’s disease with mild flare following administration of mRNA vaccine BNT162b2
We performed scRNAseq of PBMCs from three idiopathic multicentric Castleman Disease (iMCD) patients with paired flare and remission samples
ORGANISM(S): Homo sapiens 
2020-05-20 | GSE140881 | GEO
Adult-onset Still’s disease (AOSD) patients represent a population for which vaccination can induce disease flare1. The COVID-19 pandemic vaccination programs presented these patients and their health care providers with a critical decision. Previously it has been described that AOSD patients can ex...
ORGANISM(S): Homo sapiens 
2022-05-18 | GSE198549 | GEO
Background: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder characterized by unpredictable flares and variable clinical quiescence. Despite validated clinical indices like the British Isles Lupus Assessment Group (BILAG) score, reliable molecular biomarkers for monitoring d...
ORGANISM(S): Homo sapiens (Human) 
2026-06-22 | PXD075349 | Pride
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