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ProteomicsIn-depth protein profiling of mouse hippocampal postsynaptic density using data-independent acquisition proteomics
In the present study, we catalogued the proteome of postsynaptic density (PSD) derived from the hippocampus of three-week old (P19) mice. samples in 100 min gradient time.
ORGANISM(S): Mus musculus (Mouse) 
2014-09-25 | PXD000590 | Pride
Brain Postsynaptic density Hippocampus Data-independent acquisition 
ProteomicsIn-depth protein profiling of mouse hippocampal postsynaptic density using data-independent acquisition proteomics
In the present study, we catalogued the proteome of postsynaptic density (PSD) derived from the hippocampus of three-week old (P19) mice. samples in 100 min gradient time.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-08-27 | MSV000084240 | MassIVE
ProteomicsLabel-free quantification in ion-mobility enhanced data-independent acquisition proteomics
Data-dependent acquisition (DDA) methods are a well-established tool for proteome analysis and have greatly expedited the field of shotgun proteomics. However, their serial and stochastic nature restricts their reproducibility and limits the detectable dynamic range to the peptides that ionize best....
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's yeast) Escherichia coli 
2016-03-29 | PXD002393 | Pride
Proteomics Mass spectrometry Label-free quantification Ion mobility separation Data-independent acquisition 
ProteomicsUnbiased proteomic analysis of postsynaptic density fractions from Shank3 mutant mice reveals brain region specific changes highly relevant to autism spectrum disorder
Disruption of the human SHANK3 gene can cause several neuropsychiatric disease entities including Phelan-McDermid syndrome (PMS), autism spectrum disorders (ASDs) and intellectual disability (ID). Although a wide array of neurobiological studies strongly supports a major role for SHANK3 in organizin...
ORGANISM(S): Mus musculus (Mouse) 
2017-03-08 | PXD005192 | Pride
Shank3 mutants Proteomics Hippocampus Striatum Postsynaptic density (psd) 
ProteomicsK2P2.1 shapes morphology and function of brain endothelial cells via actin network remodeling
K2P2.1 (gene: Kcnk2), a two-pore domain potassium channel, is an important regulator of leukocyte transmigration across the blood-brain barrier. However, the underlying molecular mechanisms remain poorly characterized. We here show that Kcnk2-/- mouse brain microvascular endothelial cells (MBMECs) s...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-28 | PXD031051 | Pride
Actin remodeling Eae Kcnk2 Blood-brain-barrier Trek1 K2p2.1 Lc-ms/ms 
ProteomicsHowDirty: An R package to evaluate molecular contaminants in LC-MS experiments
Contaminants derived from consumables, reagents, and sample handling often negatively affect LC-MS data acquisition. In proteomics experiments, they can markedly reduce identification performance, reproducibility, and quantitative robustness. Here, we introduce a data analysis workflow combining MS1...
ORGANISM(S): Homo Sapiens (human) 
2023-10-12 | PXD044032 | JPOST Repository
ProteomicsLFQ proteomics of isolated GABAergic interneurons from mouse models of traumatic brain injury
Posttraumatic epilepsy (PTE) is a major public health concern and strongly contributes to human epilepsy cases worldwide. However, their effective treatment and prevention remains a matter of intense research. The present study provides new insights into the GABAA-receptor-stabilizing protein ubiqui...
ORGANISM(S): Mus Musculus (mouse) 
2022-07-14 | PXD031368 | JPOST Repository
ProteomicsLens Disulfide crosslink
Low glutathione levels are associated with crystallin oxidation in age-related nuclear cataract (ARNC). To understand the role of cysteine residue oxidation, we used the novel approach of comparing human cataracts with glutathione-depleted LEGSKO mouse lenses for intra- vs. intermolecular disulfide ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2016-07-20 | MSV000079952 | MassIVE
ProteomicsSubstrate profiling of the metalloproteinase ovastacin – Implications for its physiological function in mammalian fertilization
The metalloproteinase ovastacin is released by the mammalian oocyte upon fertilization and cleaves zona pellucida protein 2, a component of the surrounding extracellular matrix, at a distinct cleavage site. This limited proteolysis hardens the zona pellucida, abolishes sperm binding and thereby regu...
ORGANISM(S): Mus Musculus (mouse) 
2023-09-15 | PXD038561 | JPOST Repository
ProteomicsMultiomics analysis of Papillary thyroid cancers identifies BAIAP2L1-BRAF fusion and requirement of TRIM25, PDE5A and PKCdelta for tumorigenesis
Papillary thyroid carcinoma (PTC) is one of the most common forms of thyroid cancer with a cure rate of over 90% after surgery. However, aggressive forms may still occur, and personalized therapeutic strategies are increasingly required. We subjected patient materials from a cohort of patients whose...
ORGANISM(S): Homo Sapiens (human) 
2023-02-22 | PXD034229 | JPOST Repository
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