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ProteomicsK2P2.1 shapes morphology and function of brain endothelial cells via actin network remodeling
K2P2.1 (gene: Kcnk2), a two-pore domain potassium channel, is an important regulator of leukocyte transmigration across the blood-brain barrier. However, the underlying molecular mechanisms remain poorly characterized. We here show that Kcnk2-/- mouse brain microvascular endothelial cells (MBMECs) s...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-28 | PXD031051 | Pride
Actin remodeling Eae Kcnk2 Blood-brain-barrier Trek1 K2p2.1 Lc-ms/ms 
UnknownAlternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium.
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S-EPMC2529466 | biostudies-literature
UnknownThe potassium channel K<sub>2P</sub>2.1 shapes the morphology and function of brain endothelial cells via actin network remodeling.
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S-EPMC12274505 | biostudies-literature
UnknownProtein and Chemical Determinants of BL-1249 Action and Selectivity for K2P Channels.
Not available
S-EPMC6302903 | biostudies-literature
UnknownK2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
Not available
S-EPMC5778891 | biostudies-literature
UnknownSodium permeable and "hypersensitive" TREK-1 channels cause ventricular tachycardia.
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S-EPMC5376757 | biostudies-literature
UnknownMechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels.
Not available
S-EPMC3948252 | biostudies-literature
UnknownPiezo1 ion channels are capable of conformational signaling.
Not available
S-EPMC11427155 | biostudies-literature
UnknownPolynuclear Ruthenium Amines Inhibit K2P Channels via a "Finger in the Dam" Mechanism.
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S-EPMC7245552 | biostudies-literature
UnknownK2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Not available
S-EPMC7608817 | biostudies-literature
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