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ProteomicsFDA-approved Disulfiram Inhibits the NLRP3 Inflammasome
The NLRP3 inflammasome is dysregulated in autoinflammatory disorders caused by inherited mutations and contributes to the pathogenesis of several chronic inflammatory diseases. In this study, we discovered that disulfiram, a safe FDA-approved drug, specifically inhibits the NLRP3 inflammasome, but n...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-25 | PXD054126 | Pride
Gasdermin d Inflammasome Disulfiram 
TranscriptomicsExpression data from Disulfiram or 5-FU treated tumor-initiating hepatocellular carcinoma (HCC) cells.
Cancer stem cells (CSCs) or tumor-initiating cells (TICs) organize a cellular hierarchy in a similar fashion to normal stem cell systems and exhibit high tumorigenic activity in xenograft transplantation assay. Disulfiram (DSF) could preferentially eradicate TICs, but the molecular machinery of its ...
ORGANISM(S): Homo sapiens 
2012-11-16 | E-GEOD-42318 | biostudies-arrayexpress
TranscriptomicsExpression data from Disulfiram or 5-FU treated EpCAM-negative non-tumor-initiating hepatocellular carcinoma (HCC) cells.
Cancer stem cells (CSCs) or tumor-initiating cells (TICs) organize a cellular hierarchy in a similar fashion to normal stem cell systems and exhibit high tumorigenic activity in xenograft transplantation assay. Disulfiram (DSF) could preferentially eradicate TICs, but the molecular machinery of its ...
ORGANISM(S): Homo sapiens 
2013-03-16 | E-GEOD-45224 | biostudies-arrayexpress
ProteomicsProteomics analysis of rat liver after disulfiram treatment
Obesity has become a global health concern. A molecule that safely prevents and/or treats obesity is urgently needed. Here, we show that long-term diet supplementation of disulfiram (DSF, Antabuse®), an FDA-approved drug, abrogated the adverse impact of an obesogenic diet on insulin responsiveness, ...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-05-15 | PXD016793 | Pride
Metabolism Obesity Rat High-fat Liver Disulfiram 
GenomicsEffect of disulfiram treatment on pediatric high grade glioma
Effect of disulfiram treatment on pediatric high grade glioma
PRJNA577636 | ENA
ClinicalRepurposing disulfiram as treatment for metastatic colorectal cancerAn investigator initiated clinical phase II trial
Primary objective: Disease-control rate (complete response, partial response and/or stable disease >= 18 weeksTo investigate efficacy and safety of the treatment combination irinotecan, disulfiram and copper in patients with metastatic colorectal cancer having developed resistance to irinotecan. Pr...
2539387 | ecrin-mdr-crc
GenomicsIntestinal microbiota regulates anti-tumor effect of disulfiram combined with Cu2+
Intestinal microbiota regulates anti-tumor effect of disulfiram combined with Cu2+ Raw sequence reads
PRJNA578025 | ENA
GenomicsDisulfiram is a potential gut microbiota-dependent drug to ameliorate NASH
Disulfiram ameliorates NASH
PRJEB49623 | ENA
TranscriptomicsDisulfiram inhibits bacterial growth by inducing zinc-dependent reactive oxygen species
With the growing threat posed by emerging drug-resistant bacteria, the discovery of new antibiotics and the exploration of additional antimicrobial mechanisms of medicines currently used in the clinic are urgent. In this study, we found that disulfiram, a drug used for the treatment of alcohol addic...
ORGANISM(S): Escherichia coli 
2025-06-05 | GSE299097 | GEO
GenomicsSequencing of human hepatocellular carcinoma huh7 cell line under the effect of disulfiram [transcriptome]
Sequencing of human hepatocellular carcinoma huh7 cell line under the effect of disulfiram [transcriptome]
PRJNA1105568 | ENA
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