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ProteomicsProteome analsyis of Translocation phenomenon
Escherichia coli is the most widely used bacterial model organism and is the most commonly used host for the expression of recombinant proteins. Here we describe an unexpected protein translocation phenomenon in E. coli, whereby over-expression of recombinant proteins leads to high-level lysis-indep...
ORGANISM(S): Escherichia coli 
2018-03-02 | PXD006474 | Pride
Translocation Translatinla stress Mscl Arfa 
MetabolomicsTemporal characterization of serum metabolite signatures in lung cancer patients undergoing treatment
Lung cancer causes more deaths in men and women than any other cancer related disease. Currently, few effective strategies exist to predict how patients will respond to treatment. We evaluated the serum metabolomic profiles of 25 lung cancer patients undergoing chemotherapy ± radiation to evaluate t...
2017-01-19 | MTBLS200 | MetaboLights
TranscriptomicsStreptomyces coelicolor A3(2) strain M600 wild type transcriptome ChIP-chip with the bldC null mutant
Global regulation by the Streptomyces coelicolor atypical MerR-like transcription factor BldC. BldC is a transcriptional regulator essential for morphological development and antibiotic production in Streptomyces coelicolor. Here we identify the BldC regulon by means of chromatin immunoprecipitation...
ORGANISM(S): Streptomyces coelicolor A3(2) 
2013-01-01 | E-GEOD-28908 | biostudies-arrayexpress
ProteomicsPlasmodium falciparum PHIL1 LC-MS/MS
Plasmodium falciparum sexual-stage parasites expressing an epitope-tagged PHIL1 protein were analysed by co-IP and subsequent LC-MS/MS as
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2017-09-28 | PXD007564 | Pride
Inner membrane complex Plasmodium falciparum Phil1 Gametocyte 
MetabolomicsAnalysis of sex-specific lipid metabolism of Plasmodium falciparum points to the importance of sphingomyelin for gametocytogenesis
Male and female Plasmodium falciparum gametocytes are the parasite lifecycle stage responsible for transmission of malaria from the human host to the mosquito vector. Not only are gametocytes able to survive in radically different host environments, but they are also precursors for male and female g...
2022-04-05 | MTBLS4137 | MetaboLights
UnknownOutcomes of mechanical thrombectomy in acute stroke patients with atrial fibrillation detected after stroke versus known atrial fibrillation.
Not available
S-EPMC10961279 | biostudies-literature
TranscriptomicsDetermination of Transcription Start Sites (TSS) in Azotobacter vinelandii grown with iron, vanadium or molybdenum for 6 hours after nitrogen step-down
This experiment was to determine genome wide qualitative and quantitative differences in transcription starts under conditions of availability of iron or vanadium or molybdenum which act as co-factors for different nitrogenase isoenzymes. In response to availability of the co-factors transcription i...
ORGANISM(S): Azotobacter vinelandii DJ 
2022-06-23 | E-MTAB-11706 | biostudies-arrayexpress
UnknownUrsodeoxycholic acid versus placebo in the treatment of women with intrahepatic cholestasis of pregnancy (ICP) to improve perinatal outcomes: protocol for a randomised controlled trial (PITCHES).
Not available
S-EPMC6260710 | biostudies-literature
ProteomicsA novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1
Phenotype-based screening can identify unique small molecules that elicit a desired cellular response, but additional approaches are required to characterize their targets and mechanisms of action. Here we show that a compound termed LCS3, which selectively impairs the growth of human lung adenocarc...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD030294 | Pride
Lcs3 Thermal proteome profiling 
ProteomicsNUDCD3 deficiency disrupts V(D)J recombination to cause SCID/Omenn syndrome
Inborn errors of T cell development present a pediatric emergency in which timely curative therapy is informed by molecular diagnosis. In 9 affected patients across 3 consanguineous kindreds, we detected homozygosity for a single deleterious missense variant in the gene NudC domain containing 3 (NUD...
ORGANISM(S): Homo sapiens (Human) 
2024-09-27 | PXD035840 | Pride
Pulldown Nudcd3 Proteomics Omenn syndrome 
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