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ProteomicsDiminazene aceturate (DIZE) stabilizes atherosclerotic plaques and attenuates hepatic steatosis in apolipoprotein E knockout mice by influencing macrophages polarization and taurine biosynthesis
Atherosclerosis and nonalcoholic fatty liver disease (NAFLD) are leading causes of morbidity and mortality in the Western countries. NAFLD is an important independent risk factor for the development of atherosclerosis. The renin-angiotensin system (RAS) with its two main opposing effectors: angioten...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022829 | Pride
Atherosclerosis Dize Macrophages polarization Fatty liver Apoe-knockout mice Ace2 
GenomicsSingle cell RNA sequencing of post-radiation mouse jejunum with or without DIZE
Single cell RNA sequencing of post-radiation mouse jejunum with or without DIZE
PRJNA1298309 | ENA
GenomicsACE2 activator diminazene modulates astrocyte-mediated neuroinflammation via miR-224-5p/NLRP3 pathway and offers neuroprotection in a transgenic mouse model of Alzheimer’s disease
Objective: The protective components ACE2/Ang(1-7)/MasR of the renin-angiotensin system has been verified to play a role in Alzheimer's disease (AD). Our previous study revealed that enhancement of brain ACE2 activity, an important effector of RAS, by diminazene aceturate (DIZE) ameliorated Alzheime...
ORGANISM(S): Mus musculus 
2023-04-26 | GSE199028 | GEO
TranscriptomicsPharmacologic Activation of Angiotensin-Converting Enzyme II Alleviates Diabetic Cardiomyopathy in db/db Mice by Reducing Reactive Oxidative Stress
Angiotensin-converting enzyme 2 (ACE2) is the main key for reducing angiotensin II (Ang II) in renin-angiotensin-aldosterone system (RAAS) inducing diabetic cardiomyopathy (DCM). ACE2 modulates cardioprotective activity not only by reducing deleterious Ang II signaling but also generating the protec...
ORGANISM(S): Mus musculus 
2025-07-01 | GSE209657 | GEO
UnknownAngiotensin-converting enzyme 2 (ACE2) activator diminazene aceturate ameliorates endotoxin-induced uveitis in mice.
Not available
S-EPMC4062403 | biostudies-literature
UnknownDiminazene Aceturate Reduces Angiotensin II Constriction and Interacts with the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus 2.
Not available
S-EPMC9312513 | biostudies-literature
UnknownDiminazene aceturate attenuates hepatic ischemia/reperfusion injury in mice.
Not available
S-EPMC9616812 | biostudies-literature
UnknownAntiglaucomatous effects of the activation of intrinsic Angiotensin-converting enzyme 2.
Not available
S-EPMC3739491 | biostudies-literature
UnknownActivation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice.
Not available
S-EPMC10262141 | biostudies-literature
GenomicsACE2 activator diminazene modulates astrocyte-mediated neuroinflammation via miR-224-5p/NLRP3 pathway and offers neuroprotection in a transgenic mouse model of Alzheimer’s disease
ACE2 activator diminazene modulates astrocyte-mediated neuroinflammation via miR-224-5p/NLRP3 pathway and offers neuroprotection in a transgenic mouse model of Alzheimer’s disease
PRJNA818040 | ENA
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