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ProteomicsSpatiotemporal proteomic profiling of human cerebral development
We utilize a rapid shotgun LFQ MS method to profile four regions of developing human cerebrum. Regions encompass neural precursor rich ventricular zone, intermediate, subplate and cortex regions across human development from gestational week 16-36 and postnatal week 41 and adult brain tissue.
ORGANISM(S): Homo sapiens (Human) 
2017-07-14 | PXD004076 | Pride
Neurodevelopment Shotgun lc-msms Human ffpe tissue 
ProteomicsSpatiotemporal proteomic profiling of cerebral development
iPS cell based neuronal differentiation was used to generate pure NPCs and maturing nerons in tissue culture. LFQ mass spectrometry on Q Exactive was used to measure proteomic profile differences between the generated cell types. The identified proteomic signatures were then compared to human fetal ...
ORGANISM(S): Homo sapiens (Human) 
2017-07-14 | PXD004075 | Pride
Neuronal differentiation Lc-msms 
ProteomicsFFPE LFQ proteomics of Human Cerebral Development and CMV Encephalitis Fetal Brains
We utilize a rapid shotgun FFPE LFQ MS method to profile four regions of developing human cerebrum. Regions encompass neural precursor rich ventricular zones as well as intermediate and subplate and cortex regions accross human development from gestational weeks 16-36. Proteome signatures of the f...
ORGANISM(S): Homo sapiens (Human) 
2017-07-14 | PXD005065 | Pride
Shotgun proteomics Encephalitis Fetal brain 
ProteomicsAn anatomic proteomic atlas of human glioblastoma
Glioblastoma (GBM) is an aggressive form of brain cancer with well-established patterns of intra-tumoral heterogeneity implicated in treatment resistance, recurrence and progression. While the regional and single cell-level genetic variation of GBM have been recently resolved, downstream phenotype-l...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD019381 | Pride
Glioblastoma Laser capture microdissection Anatomical niches Lc-ms/ms 
ProteomicsTopographic mapping of the glioblastoma proteome reveals a triple axis model of intra-tumoral heterogeneity
Glioblastoma (GBM) is an aggressive form of brain cancer with well-established patterns of intra-tumoral heterogeneity implicated in treatment resistance, recurrence and progression. While regional and single cell transcriptomic variations of GBM have been recently resolved, downstream phenotype-lev...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD029290 | Pride
Proteomics Gbm Mass spectrometry 
ProteomicsShifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Rett Syndrome Neurons
Translation of many transcripts is highly regulated in the developing brain, and disturbance of translational regulation machinery contributes to neurodevelopmental disorders. In neural progenitor cells, for example, several critical pro-differentiation genes are transcribed, but their translation i...
ORGANISM(S): Homo sapiens (Human) 
2020-05-07 | PXD011961 | Pride
Rnaseq Rett syndrome Ms proteomics 
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