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UnknownDistinct metabolic signatures of Alzheimer's and Parkinson's disease revealed through genetic overlap with metabolic markers.
Metabolic dysfunction is increasingly implicated in neurodegenerative diseases, yet the genetic architecture linking metabolic markers with Alzheimer's disease (AD) and Parkinson's disease (PD) remains unclear. We systematically analysed phenotypic and genetic relationships between 249 circulating m...
S-EPMC12324630 | biostudies-literature
UnknownSex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.

Background

Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dep...
S-EPMC8458480 | biostudies-literature
UnknownElevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder.
Ankyrin-3 (ANK3) is one of the few genes that have been consistently identified as associated with bipolar disorder by multiple genome-wide association studies. However, the exact molecular basis of the association remains unknown. A rare loss-of-function splice-site SNP (rs41283526*G) in a minor is...
S-EPMC6175894 | biostudies-literature
UnknownCharting the Landscape of Genetic Overlap Between Mental Disorders and Related Traits Beyond Genetic Correlation.

Objective

Mental disorders are heritable and polygenic, and genome-wide genetic correlations (rg) have indicated widespread shared genetic risk across multiple disorders and related traits, mirroring their overlapping clinical characteristics. However, rg may underestim...
S-EPMC9633354 | biostudies-literature
UnknownHuman iPSC-Derived Spinal Cord Organoids - The First Electrophysiological Assessment of Neuronal Maturation.
The spinal cord exhibits a complex cytoarchitecture and neuronal circuitry organization that challenges in vitro replication of its functional integrity. Here we employed a previously published protocol to generate spinal cord organoids (SCOs) from human-induced pluripotent stem cells (hiPSCs). We c...
S-EPMC13495673 | biostudies-literature
UnknownGenome-wide association analysis of treatment resistant schizophrenia for variant discovery and polygenic assessment.

Background

Treatment resistant schizophrenia (TRS) is broadly defined as inadequate response to adequate treatment and is associated with a substantial increase in disease burden. Clozapine is the only approved treatment for TRS, showing superior clinical effect on overall symptomatology com...
S-EPMC11438281 | biostudies-literature
UnknownCharacterizing the Shared Genetic Underpinnings of Schizophrenia and Cardiovascular Disease Risk Factors.

Objective

Schizophrenia is associated with increased risk of cardiovascular disease (CVD), although there is variation in risk among individuals. There are indications of shared genetic etiology between schizophrenia and CVD, but the nature of the overlap remains unclear. The aim of this stu...
S-EPMC11780279 | biostudies-literature
UnknownThe estrogen hypothesis of schizophrenia implicates glucose metabolism: association study in three independent samples.

Background

Schizophrenia is a highly heritable complex psychiatric disorder with an underlying pathophysiology that is still not well understood. Metaanalyses of schizophrenia linkage studies indicate numerous but rather large disease-associated genomic regions, whereas accumulating gene- an...
S-EPMC2391158 | biostudies-literature
UnknownEnrichment of genetic markers of recent human evolution in educational and cognitive traits.
Higher cognitive functions are regarded as one of the main distinctive traits of humans. Evidence for the cognitive evolution of human beings is mainly based on fossil records of an expanding cranium and an increasing complexity of material culture artefacts. However, the molecular genetic factors i...
S-EPMC6105609 | biostudies-literature
UnknownAssociation between Genetic Variation in the Oxytocin Receptor Gene and Emotional Withdrawal, but not between Oxytocin Pathway Genes and Diagnosis in Psychotic Disorders.
Social dysfunction is common in patients with psychotic disorders. Oxytocin is a neuropeptide with a central role in social behavior. This study aims to explore the relationship between oxytocin pathway genes and symptoms related to social dysfunction in patients with psychotic disorders. We perform...
S-EPMC4303871 | biostudies-literature
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