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TranscriptomicsMolecular mechanism underline immune cell type population shift upon anti-DLL4 treatment
Molecular mechanism underline immune cell type population shift upon anti-DLL4 treatment C57BL/6 mice were injected with anti-DLL4, or an isotype control antibody as controls. Two weeks later mice were sacrificed, and thymi was harvested from 4 anti-DLL4 and 4 control animals. Total thymocytes, DN c...
ORGANISM(S): Mus musculus 
2012-04-29 | E-GEOD-24296 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse P6 retinal endothelial cells extracted from wildtype and dll4 heterozygous mice
Transcription profiling of P6 retinal endothelial cells (ECs) extracted from retinas wild_type and dll4 heterozygous mice
ORGANISM(S): Mus musculus 
2011-01-10 | E-MTAB-347 | biostudies-arrayexpress
ProteomicsDelta-like ligand 4-Notch signaling inhibition regulates pancreatic islet function and insulin secretion
Dll4-Notch signaling is required for cell fate decisions and neoplasias. However, emerging evidence suggests a role for Dll4-Notch signaling in metabolic and immune diseases. To date, there is no evidence of a direct effect of Dll4-Notch signaling inhibition on pancreatic islet function and insulin ...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-13 | PXD005333 | Pride
Gsis Dll4 Diabetes 
TranscriptomicsExpression analysis of mouse retinas after treatment with VEGF-A or Dll4-Fc.
Transcriptional profiling of retinas extracted from mouse pups 24 hours after IVT injection (at P8) of 1 microgram VEGFA, 4 micrograms Dll4-Fc, or 4 microgram hFc alone. Goal was to determine the mechanism by which inhibiting Dll4/Notch pathway is vasoprotective during retinal development. Three-co...
ORGANISM(S): Mus musculus 
2011-04-13 | E-GEOD-28516 | biostudies-arrayexpress
TranscriptomicsGene expression profile of DLL4+ and DLL4- Hemato-Endothelial Progenitors (HEPs) subpopulations
In hESCs, expression of the Notch ligand DLL4 parallels the emergence of bipotent hematoendothelial progenitors (HEPs) and promotes their hematopoietic differentiation. During differentiation, DLL4 is only expressed in a subpopulation of HEPs. To study the developmental fate of the two subpopulation...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-56881 | biostudies-arrayexpress
GenomicsRNAseq of wild type (WT) and Dll4+/- mouse lung
RNAseq of wild type (WT) and Dll4+/- mouse lung
PRJNA691759 | ENA
TranscriptomicsGene expression profile of DLL4+ and DLL4- Hemato-Endothelial Progenitors (HEPs) subpopulations
In hESCs, expression of the Notch ligand DLL4 parallels the emergence of bipotent hematoendothelial progenitors (HEPs) and promotes their hematopoietic differentiation. During differentiation, DLL4 is only expressed in a subpopulation of HEPs. To study the developmental fate of the two subpopulation...
ORGANISM(S): Homo sapiens 
2014-05-01 | GSE56881 | GEO
GenomicsDll4 inhibition promotes angiogenesis and graft volume retention in cell-assisted lipotransfer
Dll4 inhibition promotes angiogenesis and graft volume retention in cell-assisted lipotransfer
PRJNA786534 | ENA
TranscriptomicsGene expression data from T-cell progenitors developing in response to DLL4 stimulation in the plastic thymus
Since the first description of the involvement of Notch signaling in homeostasis especially of T cells, there is great effort in research to find new target genes of Notch that are involved in T cell development in the thymus. We developed a stroma cell free system that is able to induce T cell deve...
ORGANISM(S): Mus musculus 
2013-05-31 | E-GEOD-46191 | biostudies-arrayexpress
GenomicsCoronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade
Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade
PRJNA434109 | ENA
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