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In the present study, we investigated signaling pathways associated with GSIS in freshly isolated rat Islets of Langerhans. Specifically, our aim was to reveal which phosphosites and N-linked sialylated glycosylation sites that were reversible regulated upon brief glucose stimulation and link these ...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2017-11-14 | PXD007689 | Pride
Jiang2007 - GSIS system, Pancreatic Beta Cells Description of a core kinetic model of the glucose-stimulated insulin secretion system (GSIS) in pancreatic beta cells. This model is described in the article: A kinetic core model of the glucose-stimula...
2024-09-02 | BIOMD0000000239 | BioModels
PARN is essential to GSIS in beta cell
PARN is essential to GSIS in beta cells

The function of islet macrophages is poorly understood. They promote glucose-stimulated insulin secretion (GSIS) in lean mice, however, the underlying mechanism has remained unclear. We show that activation of the free fatty acid receptor FFAR4 on islet macrophages leads to interleukin-6 (IL-6) r...

2026-08-19 | MTBLS12317 | MetaboLights
We previously isolated a subclone, MIN6 clone 4, from the parental MIN6 cells, that shows well-regulated insulin secretion in response to glucose, glybenclamide, and KCl, even after prolonged culture. To investigate the molecular mechanisms responsible for preserving GSIS in this subclone, we compar...
ORGANISM(S): Mus musculus 
The pancreas plays a critical role in maintaining glucose homeostasis through the secretion of hormones from the islets of Langerhans. Glucose-stimulated insulin secretion (GSIS) by the pancreatic beta-cell is the main mechanism for reducing elevated plasma glucose. Here we present a systematic mode...
2024-01-18 | MODEL2401110001 | BioModels
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