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MetabolomicsMetabolic responses induced by DNA damage and poly (ADP-ribose) polymerase (PARP) inhibition in MCF-7 cells
Genomic instability is one of the hallmarks of cancer. Several chemotherapeutic drugs and radiotherapy induce DNA damage to prevent cancer cell replication. Cells in turn activate different DNA damage response (DDR) pathways to either repair the damage or induce cell death. These DDR pathways also e...
2015-08-01 | MTBLS177 | MetaboLights
TranscriptomicsTranscription profiling of human lymphoblastoid cell lines that are part of the NIHPDR exposed to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) to identify novel predictors of resistance to DNA damaging agents
We have investigated whether gene expression signatures can be used to predict inter-individual responses to DNA damaging agents; We used microarrays to detail inter-individual variation in gene expression across a healthy population under basal and damage induced conditions Experiment Overall Desig...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-10313 | biostudies-arrayexpress
TranscriptomicsLoss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents.
The nematode Caenorhabditis elegans has been used extensively to study responses to DNA damage. In contrast, little is known about DNA repair in this organism. C. elegans is unusual in that it encodes few DNA glycosylases and the uracil-DNA glycosylase (UDG) encoded by the ung-1 gene is the only kno...
ORGANISM(S): Caenorhabditis elegans 
2010-06-08 | E-GEOD-21467 | biostudies-arrayexpress
TranscriptomicsDNA damage responses and Mec1p
Eukaryotic cells respond to DNA damage by arresting the cell cycle and modulating gene expression to ensure efficient DNA repair. The human ATR kinase and its homolog in yeast, MEC1, play central roles in transducing the damage signal. To characterize the role of the Mec1 pathway in modulating the c...
ORGANISM(S): Saccharomyces cerevisiae 
2005-09-24 | E-GEOD-3358 | biostudies-arrayexpress
TranscriptomicsIdentifying Novel Predictors of Resistance to DNA Damaging Agents
We have investigated whether gene expression signatures can be used to predict inter-individual responses to DNA damaging agents We used microarrays to detail inter-individual variation in gene expression across a healthy population under basal and damage induced conditions Keywords: dose (MNNG)
ORGANISM(S): Homo sapiens 
2008-09-23 | GSE10313 | GEO
ClinicalChemotherapy With DNA Damaging Agents In Colorectal Cancer
Chemotherapy Treatment alone with DNA damaging drugs might be as effective as chemotherapy combined with surgery in colorectal cancer (CRC) avoiding surgery complications.
2114543 | ecrin-mdr-crc
TranscriptomicsSigG does not control gene expression in response to DNA damage in Mycobacterium tuberculosis H37Rv.
The expression of the Mycobacterium tuberculosis sigma factor, sigG, was induced by a variety of DNA damaging agents but inactivation of sigG did not affect induction of gene expression or bacterial survival under these conditions. Therefore, SigG does not control the DNA repair response of M. tuber...
ORGANISM(S): Mycobacterium tuberculosis 
2011-04-15 | E-BUGS-111 | biostudies-arrayexpress
GenomicsComprehensive interrogation of chemo-genomic interactions between DNA damaging agents and DNA damage repair genes with targeted CRISPR knockout screening
Comprehensive interrogation of chemo-genomic interactions between DNA damaging agents and DNA damage repair genes with targeted CRISPR knockout screening
PRJNA1277588 | ENA
TranscriptomicsAccumulation of sumoylated Rad52 in checkpoint mutants perturbed in DNA replication
Checkpoints are cellular surveillance and signaling pathways that regulate responses to DNA damage and perturbations of DNA replication. Here we show that high levels of sumoylated Rad52 are present in the mec1 sml1 and rad53 sml1 checkpoint mutants exposed to DNA damaging agents such as methyl meth...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-18 | E-GEOD-14761 | biostudies-arrayexpress
GenomicsSuppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA
Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA
PRJNA658317 | ENA
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