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TranscriptomicsNon redundant functions of ATM and DNAPKcs in response to clean DNA Double Strand Breaks.
DNA Double Strand Breaks (DSBs) are harmful lesions that require rapid detection and repair in order to avoid toxic genomic rearrangements. DSBs elicit the so called DNA Damage Response (DDR), largely relying on ataxia telangiectasia mutated (ATM) and DNA Protein Kinase (DNAPK), two members of the P...
ORGANISM(S): Homo sapiens 
2015-09-30 | E-MTAB-2992 | biostudies-arrayexpress
UnknownThe SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation.
Not available
S-EPMC4888775 | biostudies-literature
TranscriptomicsDNA-dependent protein kinase drives prostate cancer progression through transcriptional regulation of the Wnt signaling pathway
DNAPK was identified as the most significantly expressed kinase associated with metastatic progression in high-risk prostate cancer. GSEA analysis on DNAPK knockdwon samples and on patient data nominated Wnt signaling as the top pathway associated with DNAPK Our data indicates that DNAPK regulates W...
ORGANISM(S): Homo sapiens 
2019-10-01 | GSE116895 | GEO
ProteomicsHuman U2OS DNApk GLASS-ChIP LC-MS/MS
The Mre11-Rad50-Nbs1 (MRN) complex recognizes and processes DNA double-strand breaks for homologous recombination by performing short-range removal of 5ʹ strands. Endonucleolytic processing by MRN requires a stably bound protein at the break site—a role we postulate is played by DNA-dependent protei...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD045033 | Pride
Human U2os Glass-chip Dnapk Lc-ms/ms 
TranscriptomicsGene Expression Profile of Medullary Epithelial Cells isolated from thymus of Bone Marrow (BM) reconstituted RAG1 null (control) and SCID NOD mouse
We identified DNAPK as one of the major proteins that physically interact with Autoimmune regulator (Aire). To establish physiological significance of DNAPK in Aire-driven expression of PTA genes in MECs, we utilized BM-reconstituted SCID mice (which express non functional DNAPK in their MECs) and R...
ORGANISM(S): Mus musculus 
2010-10-16 | E-GEOD-24734 | biostudies-arrayexpress
TranscriptomicsGene Expression Profile of Medullary Epithelial Cells isolated from thymus of Bone Marrow (BM) reconstituted RAG1 null (control) and SCID NOD mouse
We identified DNAPK as one of the major proteins that physically interact with Autoimmune regulator (Aire). To establish physiological significance of DNAPK in Aire-driven expression of PTA genes in MECs, we utilized BM-reconstituted SCID mice (which express non functional DNAPK in their MECs) and R...
ORGANISM(S): Mus musculus 
2010-10-16 | GSE24734 | GEO
UnknownDNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway.
Not available
S-EPMC6744969 | biostudies-literature
UnknownProstate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts.
Not available
S-EPMC3104752 | biostudies-literature
UnknownThe crucial role of DNA-dependent protein kinase and myelin transcription factor 1-like protein in the miR-141 tumor suppressor network.
Not available
S-EPMC6791708 | biostudies-literature
GenomicsDNA-dependent protein kinase drives prostate cancer progression through transcriptional regulation of the Wnt signaling pathway
DNA-dependent protein kinase drives prostate cancer progression through transcriptional regulation of the Wnt signaling pathway
PRJNA480511 | ENA
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