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ProteomicsDNMT1 IP-MS alalysis to identify ubiquitin-dependent interacting partners
Stable inheritance of DNA methylation is critical for maintaining the differentiated phenotypes in multicellular organisms. However, the molecular basis ensuring high fidelity of maintenance DNA methylation is largely unknown. Here, we demonstrate that two distinct modes of DNMT1 recruitment, one is...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2020-02-25 | PXD015282 | Pride
Dnmt1 ubiquitin 
TranscriptomicsExpression data of Dnmt1 haploinsufficient leukemia stem cells and bulk leukemia
Leukemia stem cells (LSCs) are an attractive target in treatment of many types of blood cancers. There remains an incomplete understanding of the epigenetic mechanisms driving LSC formation and maintenance, and how this compares to the epigenetic regulation of normal hematopoietic stem cells (HSCs)....
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-31626 | biostudies-arrayexpress
TranscriptomicsPost-transcriptional fine-tuning of COP9 signalosome subunit biosynthesis is regulated by the c-Myc/Lin28B/let-7 pathway
The COP9 signalosome (CSN) is a conserved protein complex occurring in all eukaryotes. The mammalian CSN consists of eight subunits (CSN1 – CSN8) and possesses an intrinsic metalloprotease JAMM motif localised to CSN5. In addition, it is associated with kinases such as protein kinase CK2 and D and t...
ORGANISM(S): Homo sapiens 
2011-10-26 | E-GEOD-19085 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of uhrf1 mutant zebrafish
UHRF1 (Ubiquitin-like, containing PHD and RING finger domains, 1) recruits DNMT1 to hemimethylated DNA during replication, is essential for maintaining DNA methylation patterns during cell division and is suggested to direct additional repressive epigenetic marks. Uhrf1 mutation in zebrafish results...
ORGANISM(S): Danio rerio 
2015-02-09 | E-GEOD-55339 | biostudies-arrayexpress
UnknownDNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination.
Not available
S-EPMC4528052 | biostudies-literature
ProteomicsProteome data on human MDS-L cells
Shotgun mass spectrometric analysis of WT and TOPORS KO MDS-L cells
ORGANISM(S): Homo Sapiens (human) 
2024-03-08 | PXD048275 | JPOST Repository
ProteomicsMS data on ubiquitinated proteins
Mass spectrometric analysis of ubiquitinated proteins in MDS-L cells
ORGANISM(S): Homo Sapiens (human) 
2024-03-08 | PXD044347 | JPOST Repository
UnknownInhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization.
Not available
S-EPMC11358161 | biostudies-literature
UnknownMethylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase.
Not available
S-EPMC5915600 | biostudies-literature
UnknownE3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1.
Not available
S-EPMC10163782 | biostudies-literature
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