Sort   by:  
 Page size 
ProteomicsCathepsin B Promotes Aβ Proteotoxicity by Modulating Aging Regulating Mechanisms
While the activities of certain proteases promote proteostasis and prevent neurodegeneration-associated phenotypes, the protease cathepsin B (CTSB) enhances proteotoxicity in Alzheimer’s disease (AD) model mice, and its levels are elevated in brains of AD patients. How CTSB exacerbates the toxicity ...
ORGANISM(S): Caenorhabditis elegans 
2024-09-04 | PXD045561 | Pride
Cathepsin b C. elegans Aβ proteotoxicity 
ProteomicsCross-Linking Mass Spectrometry (CXMS) of human pre-60S ribosomal particles
Cross-Linking Mass Spectrometry (CXMS) analysis of human pre-60S ribosomal particles.
ORGANISM(S): Homo Sapiens 
2020-05-07 | PXD019025 |
TranscriptomicsBrd7, a novel PBAF-specific SWI/SNF subunit, is required for gene activation and repression in embryonic stem cells
The composition of chromatin remodeling complexes dictates how these enzymes control transcriptional programs and cellular identity. Here, we investigate the composition of SWI/SNF complexes in embryonic stem cells (ESCs). In contrast to differentiated cells, ESCs have a biased incorporation of cert...
ORGANISM(S): Mus musculus 
2010-03-04 | E-GEOD-7791 | biostudies-arrayexpress
ProteomicsC. elegans SGK-1 IP-MS - Serum- and Glucocorticoid-Inducible Kinase-1 (SGK-1) Plays a Role in Membrane Trafficking in Caenorhabditis elegans
We performed an IP against SGK-1::GFP and the candidate interacting proteins have been identified by MS.
ORGANISM(S): Caenorhabditis elegans 
2015-06-29 | PXD002190 | Pride
C. elegans sgk-1 ip-ms 
ProteomicsDiverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomal particles
Ribosome biogenesis is a highly complex process in eukaryotes, involving temporally and spatially regulated ribosomal protein (r-protein) binding and rRNA remodeling events in the nucleolus, nucleoplasm and cytoplasm. Hundreds of assembly factors (AFs), organized into sequential functional groups, f...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-06-01 | PXD003736 | Pride
Assembly factors Cryo-em Pre-60s ribosome Cxms 
ProteomicsSAD-1 kinase controls presynaptic phase separation by relieving SYD-2/Liprin-? autoinhibition
C. elegans SAD-1 kinase in vitro phosphorylation of SYD-2.
ORGANISM(S): Caenorhabditis Elegans (ncbitaxon:6239) 
2023-03-10 | MSV000091471 | MassIVE
ProteomicsCharacterization of progressive denaturation and unfolding intermediates of proteins by fast cross-linking using di-ortho-phthalaldehyde
Chemical cross-linking of proteins coupled with mass spectrometry (CXMS) is widely used in protein structural analysis. In this study we develop a new class of non-hydrolyzable amine-selective di-ortho-phthalaldehyde (DOPA) cross-linkers, one of which is DOPA2. Cross-linking of proteins with DOPA2 i...
ORGANISM(S): Staphylococcus Aureus Bos Taurus 
2021-12-20 | PXD030552 |
ProteomicsImproving Mass Spectrometry Analysis of Protein Structures with Arginine-Selective Chemical Cross-linkers
we develop a series of arginine selective bifunctional aromatic glyoxal cross-linkers (ArGOs) and demonstrate their ability to cross-link model proteins and a protein complex. We also introduce the first arginine-lysine heterobifunctional cross-linker (KArGO), which provides significantly greater su...
ORGANISM(S): Escherichia Coli 
2019-01-14 | PXD012341 |
ProteomicsA proteomics data analysis protocol using Open-pFind
High-throughput proteomics based on mass spectrometry (MS) analysis has permeated biomedical science and propelled numerous research projects. pFind 3 is a database search engine for high-speed and in-depth proteomics data analysis (Chi et al. 2018). pFind 3 features a swift open search workflow tha...
ORGANISM(S): Homo Sapiens Caenorhabditis Elegans 
2021-01-31 | PXD023901 |
ProteomicsSAD-1 kinase controls presynaptic phase separation by relieving SYD-2/Liprin-α autoinhibition.
Identify the substrate of SAD-1 Kinase and investigate their function in presynaptic phase separation.
ORGANISM(S): Caenorhabditis Elegans 
PXD043081 |
Sort   by:  
 Page size