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MetabolomicsSpermine is a natural suppressor of AR signaling in castration-resistant prostate cancer
In castration-resistant prostate cancer (CRPC), clinical response to androgen receptor (AR) antagonists is limited mainly due to AR-variants expression and restored AR signaling. The metabolite spermine is most abundant in prostate and it decreases as prostate cancer progresses, but its functions re...
2023-10-11 | MTBLS8034 | MetaboLights
UnknownGenome sequence of the agarwood tree Aquilaria sinensis (Lour.) Spreng: the first chromosome-level draft genome in the Thymelaeceae family.
Not available
S-EPMC7050300 | biostudies-literature
ProteomicsIntegrated Landscape of Plasma Metabolism and Proteome for Post-traumatic Deep Vein Thrombosisasma Metabolism and Proteome for Post-traumatic Deep Vein Thrombosis
Deep vein thrombosis (DVT) is a leading cause of morbidity and mortality after trauma. Here, we integrate metabolomics and proteomics in up to 680 individuals with and without DVT after trauma (pt-DVT) to reveal the metabolic alterations and their function, and provide potential biomarkers. We carri...
ORGANISM(S): Homo Sapiens 
2024-07-22 | PXD054131 |
ProteomicsLabel-free proteomics of endometrial epithelial cell for identification of presumptive biomarkers of endometritis
A total of 1180 proteins were identified in the control group and endometritis model group, of which 313 differential proteins were accurately quantified. The proteomic results were verified by WB, TEC and IF techniques, and the same conclusion was obtained.
ORGANISM(S): Capra Hircus 
2022-05-18 | PXD033950 |
ProteomicsProteomic study on lavage fluid of Dairy cows 30 days after delivery
Lipopolysaccharide (LPS) is a component of the outer membrane of gram-negative bacteria that is involved in pathogenic processes leading to postpartum metritis and endometritis in dairy cow. It also causes inflammation of the endometrium. This study aimed to investigate the effects of LPS on cow end...
ORGANISM(S): Bos Taurus 
2022-08-23 | PXD036248 |
ProteomicsIntegrated proteomic and transcriptomic analyses reveal the roles of Brucella BI-1 in cell division and membrane homeostasis of Brucella suis S2
To explore the role of Brucella BI-1 in Brucella suis S2, we constructed the Brucella BI-1 deletion mutant strain and its complementary strain. We then determined the effect of Brucella BI-1 deletion on the physiological characteristics of Brucella suis S2 and revealed them via integrated transcript...
ORGANISM(S): Brucella Suis Bv. 1 Str. S2 
2020-11-13 | PXD022537 |
ProteomicsMechanistic Insight into Glioma Through Spatially Multidimensional Proteomics
Characterizing the tumor microenvironment at the molecular level is essential for understanding the mechanisms of tumorigenesis and evolution. However, the specificity of the blood proteome in localized region of the tumor and its linkages with other systems is difficult to investigate. Here, we pro...
ORGANISM(S): Homo Sapiens 
2023-07-20 | PXD043970 |
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