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TranscriptomicsInvestigating the effects of Ceylon cinnamon water extract and metformin on HepG2 cells for type 2 diabetes therapy
performing high-throughput RNA sequencing (RNA-Seq) transcriptomic analysis of hepatic cells after metformin or CWE treatment to identify changes in diabetes-related gene expression. Outcomes of this project provide evidence for the effectiveness of Ceylon cinnamon water extract compared to the cur...
ORGANISM(S): Homo sapiens 
2022-02-14 | E-MTAB-11418 | biostudies-arrayexpress
ProteomicsNovel Kinesin Family 1A Variants Linked to Atypical Parkinsonism Elicit Altered Neuronal TDP-43 Interactions and Dendritic Atrophy
We used patient induced pluripotent stem cells (IPSC) derived neurons from a patient with two mutations in KIF1A to evaluate the quantitative changes to KIF1A protein interaction, relative to wild-type control IPSC-motor neurons, using an anti-KIF1A antibody during immunoprecipitation. Given the rel...
ORGANISM(S): Homo sapiens (Human) 
2025-08-26 | PXD067234 | Pride
Kif1a Ipsc motor neurons Tdp-43 
ProteomicsGlobal Landscape of Cell Envelope Protein Complexes in Escherichia coli
After extraction with mild non-denaturing detergents, we affinity-purified 785 endogenously-tagged CEPs and then identified stably-associated polypeptides by precision mass spectrometry. The resulting high-quality physical interaction network, comprising most (77%) of all targeted CEPs, revealed hu...
ORGANISM(S): Escherichia coli (strain K12 / W3110 / ATCC 27325 / DSM 5911) 
2017-11-30 | PXD006247 | Pride
Escherichia coli Multi-protein complexes Macromolecues Protein-protein interactions Cell envelope Cell envelope proteins Cell envelope protein complexes 
UnknownThe human genome contains over a million autonomous exons.
Not available
S-EPMC10760453 | biostudies-literature
TranscriptomicsTranscription profiling of field-caught permethrin-resistant Anopheles gambiae shows over-expression of CYP6P3, a P450 that metabolizes pyrethroids
Field-caught permethrin-resistant Anopheles gambiae s.s. overexpress CYP6P3, a P450 that metabolizes pyrethroids
ORGANISM(S): Anopheles gambiae s.s. 
2009-01-17 | E-MTAB-52 | biostudies-arrayexpress
UnknownNortheast Yucatan hurricane activity during the Maya Classic and Postclassic periods.
Not available
S-EPMC9684114 | biostudies-literature
GenomicsA TAD boundary is preserved upon deletion of the CTCF-rich Firre locus
A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus
PRJNA385778 | ENA
ProteomicsMAPPING HEART FIBROSIS: INTEGRATIVE PHOSPHOPROTEOMIC PROFILING OF CLINICAL SAMPLES, ANIMAL AND ORGAN-ON-A-CHIP MODELS
Precision mass spectrometry, animal models and organ-on-a-chip (OOC) systems have emerged as promising experimental strategies to study the molecular mechanisms governing human biology and disease, including the molecular basis of cardiovascular disorders like fibrosis where access to patient sample...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-11-12 | PXD011107 | Pride
Human Mouse model Heart Hypertrophy Phosphoproteomic Organ-on-a-chip Fibrosis 
UnknownMicroRNA-570 is a novel regulator of cellular senescence and inflammaging.
Not available
S-EPMC6338629 | biostudies-literature
TranscriptomicsDifferences between C9ORF72 iPS neuronal and Control and SOD1D90A iPS neuronal transcriptomes
The purpose of this experiment was to compare differences in the transcript levels between RNA samples from induced pluripotent stem cells differentiated into neurons carrying a mutation in the SOD1 gene, an expanded GGGGCC repeat mutation in the chromosome 9 open reading frame 72 gene and those wit...
ORGANISM(S): Homo sapiens 
2013-10-29 | E-MTAB-1927 | biostudies-arrayexpress
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