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TranscriptomicsGene expression profiling of BRCA1-mutated breast tumors
Background: Breast cancer is a complex disease, encompassed by different clinically and molecularly stratified entities. In 2000, Perou and colleagues demonstrated that tumor phenotypic diversity correlates with differences in global gene expression patterns, which in turn reflect aspects of the bio...
ORGANISM(S): Homo sapiens 
2009-10-14 | E-GEOD-12350 | biostudies-arrayexpress
TranscriptomicsIntrauterine growth restriction is associated with cardiac ultrastructural and gene expression changes related to the energetic metabolism in a rabbit model
Intrauterine growth restriction (IUGR) affects 7-10% of pregnancies and is associated with cardiovascular remodeling and dysfunction which persists into adulthood. The underlying subcellular remodeling and cardiovascular programming events are still poorly documented. Cardiac muscle is central in th...
ORGANISM(S): Oryctolagus cuniculus 
2013-10-30 | E-GEOD-37860 | biostudies-arrayexpress
TranscriptomicsGene expression profiling upon PI3K inhibition using different inhibitors
Activation of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is one the most frequent genetic events in human cancer. Therefore, the development of PI3K inhibitors has attracted much attention. We previously described the pyrazolopyrimidine derivative ETP-45658 as a potent inhibitor of P...
ORGANISM(S): Homo sapiens 
2014-04-08 | E-GEOD-56579 | biostudies-arrayexpress
TranscriptomicsMicroarray Expression Data from Haematopoietic Differentiated Human Embryonic Stem Cells
The underlying mechanisms which are responsible and govern early haematopoietic differentiation during development are poorly understood. Gene expression comparison between pluripotent human embryonic stem cells and earliest haematopoietic progenitors may reveal novel transcripts and pathways and p...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-29115 | biostudies-arrayexpress
TranscriptomicsComparative gene expression profile of Ngn3-overexpressing cultured hippocampal neurons vs the corresponding control populations
Gene expression profiles of Ngn3-overexpressing cultured hippocampal neurons was compared to the profile of the corresponding control populations. (neurons expressing GFP). Neurogenin3, a proneural transcription factor controlled by Notch receptor, is involved in hippocampal neuron differentiation ...
ORGANISM(S): Mus musculus 
2011-01-27 | E-GEOD-26911 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of tumor infiltrating CD11c + cells in ItgaxΔPtpn6 model
This study investigates the role of dendritic cells (DCs) in anti-tumor immunity, focusing on the phosphatase SHP-1 and its regulation of signaling pathways and interactions with CD8+ T cells. Using conditional knockout mouse models and single-cell transcriptomics, we show that SHP-1 loss in convent...
ORGANISM(S): Mus musculus 
2026-04-15 | E-MTAB-16912 | biostudies-arrayexpress
TranscriptomicsComparative gene expression profile of Cux2 knock-out cortex
Gene expression profiles of Cux2 ko cortex was compared to the profile of WT cortex. Keywords: tissue comparison Cerebral cortex of WT and Cux2 ko animals were dissected and total RNA was obtained. Gene expression profiles were obtained for each sample and compared.
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-14971 | biostudies-arrayexpress
TranscriptomicsIncreased levels of aneuploidy and deregulation of ploidy controlling genes are associated with maintained cultures of hMSC
Human mesenchymal stem cells (hMSC) are being successfully evaluated for the treatment of a wide range of pathological conditions, including graft versus host disease (GVHD), bone and cartilage degeneration, complex fistula and myocardial infarction. Many of these clinical trials use hMSC, which hav...
ORGANISM(S): Homo sapiens 
2012-10-30 | E-GEOD-39250 | biostudies-arrayexpress
TranscriptomicsmiR-335 regulates cell migration and differentiation in human mesenchymal stem cells
Human mesenchymal stem cells (hMSC) have an extensive potential for clinical applications in cell therapy. However, very little is known of the specific molecular regulatory mechanisms that control the therapeutical properties of these cells. We aimed to identify microRNAs (miRNAs) that could be inv...
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-19232 | biostudies-arrayexpress
TranscriptomicsAnalysis of TLS activity in PGC-1alpha+/+ and PGC-1alpha-/- hepatocytes
We found that TLS can work as a PGC-1alpha cofactor and this assay was carried out to test the functional dependency of TLS on PGC-1alpha on a whole genome scale Three independently-isolated cultures of primary hepatocytes from PGC-1α+/+ and PGC-1α-/- mice were infected with shTLS or control adeno...
ORGANISM(S): Mus musculus 
2013-07-26 | E-GEOD-23242 | biostudies-arrayexpress
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