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UnknownComprehensive RNA-Seq Analysis of Potential Therapeutic Targets of Gan-Dou-Fu-Mu Decoction for Treatment of Wilson Disease Using a Toxic Milk Mouse Model.
Not available
S-EPMC8082393 | biostudies-literature
ProteomicsALKBH7, a mitochondrial member of AlkB family, binds histones in vitro, part 2
Human genome encodes 9 AlkB family members, one of which is ALKBH7. In this study, we found recombinant ALKBH7 could bind bulk histones in GST pull-down and attenuate the signal of H4K20me2 in demethylation assays. With mass spectrometry, we also identified several potential ALKBH7-interacting prote...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD008319 | Pride
Alkbh7 mitochondrion histone 
ProteomicsALKBH7, a mitochondrial member of AlkB family, binds histones in vitro, part 1
Human genome encodes 9 AlkB family members, one of which is ALKBH7. In this study, we found recombinant ALKBH7 could bind bulk histones in GST pull-down and attenuate the signal of H4K20me2 in demethylation assays. With mass spectrometry, we also identified several potential ALKBH7-interacting prote...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD008318 | Pride
Alkbh7 mitochondrion histones 
ProteomicsTMT-labeled quantitative protein profiling of hippocampus during human aging
Human hippocampus is one of the critical brain regions affected by aging. However, a fully understanding of aging-related changes in protein profiles in human hippocampus has not been well described, especially for the Chinese population. With the newly founded human brain bank in Chinese Academy of...
ORGANISM(S): Homo sapiens (Human) 
2016-04-13 | PXD001987 | Pride
Human Aging Hippocampus 
ProteomicsALKBH7, a mitochondrial member of AlkB family, binds histones in vitro, part 3
Human genome encodes 9 AlkB family members, one of which is ALKBH7. In this study, we found recombinant ALKBH7 could bind bulk histones in GST pull-down and attenuate the signal of H4K20me2 in demethylation assays. With mass spectrometry, we also identified several potential ALKBH7-interacting prote...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD008320 | Pride
Alkbh7 mitochondrion histone 
ProteomicsProteomic profiling of sclerosis hippocampus revealed dysregulated packaging of vesicular neurotransmitters in temporal lobe epilepsy
Proteomics and bioinformatic analyses of hippocampus were performed. High-resolution liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), in combination with TMT-6plex quantification, was applied for global protein expression analysis. The proteomics results were validated by Wester...
ORGANISM(S): Homo sapiens (Human) 
2020-07-17 | PXD010544 | Pride
Temporal lobe epilepsy Proteomics Vesicle transmitters packaging Hippocampus sclerosis Annexin 
ProteomicsProteomic profiling of sclerosis hippocampus revealed dysregulated packaging of vesicular neurotransmitters in temporal lobe epilepsy
Proteomics and bioinformatic analyses of hippocampus were performed. High-resolution liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), in combination with TMT-6plex quantification, was applied for global protein expression analysis. The proteomics results were validated by Wester...
ORGANISM(S): Homo sapiens (Human) 
2020-07-17 | PXD010543 | Pride
Temporal lobe epilepsy Proteomics Vesicle transmitters packaging Hippocampus sclerosis Annexin 
MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
UnknownFirst Clinical Study on Long-Acting Growth Hormone Therapy in Children with Turner Sydrome.
Not available
S-EPMC9192150 | biostudies-literature
ProteomicsTMT-labeled quantitative protein profiling of hippocampus during human aging
Human hippocampus is one of the critical brain regions affected by aging. However, a fully understanding of aging-related changes in protein profiles in human hippocampus has not been well described, especially for the Chinese population. With the newly founded human brain bank in Chinese Academy of...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080710 | MassIVE
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