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ProteomicsMechanisms associated with systemic effects of cancer
Cancer is considered as a disease of a specific organ, but its effects are felt throughout the body. The systemic effects of cancer can lead to weakness in muscles and heart, which hastens cancer-associated death. miR-486 is a myogenic microRNA and its reduced expression in skeletal muscle is observ...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-19 | PXD028554 | Pride
Breast cancer Lc-msms Mouse Functional limitations Skeletal muscle Mir-486 
ProteomicsMechanisms associated with systemic effects of cancer
Cancer is considered as a disease of a specific organ, but its effects are felt throughout the body. The systemic effects of cancer can lead to weakness in muscles and heart, which hastens cancer-associated death. The majority of preclinical studies, including our own, on cancer-induced skeletal mus...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD034000 | Pride
Breast cancer Muscle stem cells Skeletal muscle Lc-msms. Mir-486 Cancer cell line Human Biomarker 
ProteomicsCryo-EM Structures of Prion protein filaments from Gerstmann-Sträussler-Scheinker disease
Aggregation of the prion protein (PrP) and formation of PrP amyloid (APrP) is severe in some Prion diseases. In the dominantly inherited prion protein amyloidosis known as Gerstmann-Sträussler-Scheinker (GSS) disease, plaques made of PrP amyloid are a distinct feature. The TTC to TCC mutation in Pr...
ORGANISM(S): Homo sapiens (Human) 
2022-07-18 | PXD032402 | Pride
Cryo-em structures of prion protein filaments from gerstmann-sträussler-scheinker disease 
ProteomicsThe kidney releases in the urine and circulation a non-polymerizing form of Uromodulin that retains the external hydrophobic patch domain
Uromodulin (Tamm-Horsfall protein, THP) is a glycoprotein uniquely produced in the kidney. It is released by cells of the thick ascending limbs (TAL) apically in the urine, and basolaterally in the renal interstitium and systemic circulation. Processing of mature urinary THP, which polymerizes into ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-08 | PXD027914 | Pride
Uromodulin Lc-msms Aki External hydrophobicpatch domain Urine Serum Elisa Human 
ProteomicsTumor tissue collection and processing under physioxia allows highly relevant detection of signaling networks and drug sensitivity of cancer cells
Preclinical studies of primary cancer cells are always done after tumors are removed from patients or animals at ambient atmospheric oxygen (O2, ~21%). However, O2 concentrations in organs are in the ~3-10% range, with most tumors in an hypoxic or 1-2% O2 environment in vivo. Although effects of O2 ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD023133 | Pride
Mouse Tumor Lc-ms/ms 
ProteomicsDisulfide bonds are critical for stabilizing cell division, cell envelope biogenesis, and antibiotic resistance proteins in mycobacteria
Mycobacterium, including Mycobacterium tuberculosis, the etiological agent of tuberculosis, have a unique cell envelope critical for their survival and antibacterial resistance. The cell envelope's assembly and maintenance influence permeability, making it a key target against multidrug resistant st...
ORGANISM(S): Mycobacterium Smegmatis Str. Mc2 155 (ncbitaxon:246196) 
2025-01-16 | MSV000096877 | MassIVE
ProteomicsMapping the anti-cancer activity of alpha-connexin carboxyl-terminal (aCT1) peptide in resistant HER2+ breast cancer
Connexin 43 (Cx43) is a protein encoded by the GJA1 gene and is a component of cell membrane structures called gap junctions, which facilitate intercellular communication. Prior evidence indicates that elevated GJA1 expression in the HER2-positive (HER2+) subtype of breast cancer is associated with ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-01 | MSV000093550 | MassIVE
ProteomicsCharacterization of BioID tagging systems in budding yeast and exploring the interactome of the Ccr4-Not complex
The modified E. coli biotin ligase BirA* was the first developed for proximity labeling of proteins (BioID). However, it has low activity at temperatures below 37 C, which reduces its effectiveness in organisms growing at lower temperatures, such as budding yeast. Multiple derivatives of the enzymes...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2024-05-02 | MSV000094663 | MassIVE
ProteomicsCharacterization of Endoplasmic Reticulum-Associated Degradation in the human fungal pathogen C. albicans
C. albicans is the most prevalent human fungal pathogen. In immunocompromised individuals, C. albicans can cause serious systemic disease and patients infected with drug-resistant isolates have few treatment options. The Ubiquitin-Proteasome System has not been thoroughly characterized in C. albica...
ORGANISM(S): Candida Albicans (ncbitaxon:5476) 
2023-05-03 | MSV000091843 | MassIVE
ProteomicsProteomic Analyses of Plasma from Patients with Fracture Related Infection Reveals Systemic Activation of the Complement and Coagulation Cascades
Patients/Participants: Twenty-seven patients meeting confirmatory FRI criteria were matched to 27 controls based on fracture region, age, and time after surgery Intervention: Tandem Mass Tag (TMT) LC-MS analysis of patient plasma samples Main Outcome Measurements: Abundances for over 1000 proteins w...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-15 | MSV000093116 | MassIVE
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