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ProteomicsMapping the DPP9 Interactome by Proximity Labeling
Dipeptidyl peptidase 9 (DPP9) is an amino peptidase with the unusual ability to cleave a peptide bond post-proline. Its function affects immunity, DNA-repair, cell signaling, memory and neonatal survival; its dysregulation is linked to cancer and immune-related disorders. While most studies focus on...
ORGANISM(S): Homo sapiens (Human) 
2026-08-31 | PXD067345 | Pride
Proximity labeling Dpp9 Turboid 
ProteomicsDPP9 activity and not protein binding inhibits the CARD8 inflammasome
Inflammasomes are multiprotein complexes formed in response to pathogens. NLRP1 and CARD8 are related proteins that form inflammasomes, but the pathogen-associated signal(s) and the molecular mechanisms controlling their activation have not been established. Inhibitors of the serine dipeptidyl pept...
ORGANISM(S): Homo sapiens (Human) 
2019-10-23 | PXD015047 | Pride
Val-boropro Card8 Dpp9 
GenomicsReverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency
Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency
PRJNA1468981 | ENA
GenomicsDPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma
DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma
PRJNA1013351 | ENA
TranscriptomicsReverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency
Loss of function mutation in the human DPP9 gene causes Hatipoglu syndrome leading to severe inflammasomopathy. A key feature of the disease is pancytopenia and patients require bone marrow transplantation, but the mechanism of cell loss is unclear since Dpp9 mutant mice have normal hematopoiesis, s...
ORGANISM(S): Homo sapiens 
2026-06-01 | GSE332722 | GEO
UnknownDPP9 as a Potential Novel Mediator in Gastrointestinal Virus Infection.
Not available
S-EPMC9686780 | biostudies-literature
UnknownDPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Not available
S-EPMC8299537 | biostudies-literature
ProteomicsDPP9 KD and OE hippocampal proteome and AP-MS of DPP9 in hippocampus
Dipeptidyl peptidase 9 (DPP9) has been extensively studied for its role in inflammation and cancer. Proteomics analysis identified differentially expressed proteins associated with memory retrieval regulated by DPP9. DPP9-interacting proteins are involved in dendritic spine and axon function, and tw...
ORGANISM(S): Mus Musculus 
2023-08-21 | PXD044715 |
UnknownDPP9's Enzymatic Activity and Not Its Binding to CARD8 Inhibits Inflammasome Activation.
Not available
S-EPMC6862324 | biostudies-literature
UnknownStructural and biochemical mechanisms of NLRP1 inhibition by DPP9.
Not available
S-EPMC8081665 | biostudies-literature
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