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ProteomicsGlobal proteomics of HEK293T cells treated with Val-boroPro for 48h
Global proteomics of HEK293T cells treated with Val-boroPro for 48h
ORGANISM(S): Homo sapiens (Human) 
2020-10-14 | PXD015978 | Pride
Val-boropro Tmtsixplex 
GenomicsRNA-seq of HEK 293T cells treated with Val-boroPro
RNA-seq of HEK 293T cells treated with Val-boroPro
PRJNA643846 | ENA
TranscriptomicsRNA-seq of HEK 293T cells treated with Val-boroPro
We report the application of RNA-seq for profiling gene transcription upon treatment of dipeptidyl peptidases 8 and 9 inhibitor, Val-boroPro (VbP). We find no significant changes in gene transcription upon treatment of mammalian cells with Val-boroPro.
ORGANISM(S): Homo sapiens 
2020-09-23 | GSE153744 | GEO
UnknownElectrical stimulation inhibits Val-boroPro-induced pyroptosis in THP-1 macrophages via sirtuin3 activation to promote autophagy and inhibit ROS generation.
Not available
S-EPMC7185124 | biostudies-literature
ProteomicsDPP9 activity and not protein binding inhibits the CARD8 inflammasome
Inflammasomes are multiprotein complexes formed in response to pathogens. NLRP1 and CARD8 are related proteins that form inflammasomes, but the pathogen-associated signal(s) and the molecular mechanisms controlling their activation have not been established. Inhibitors of the serine dipeptidyl pept...
ORGANISM(S): Homo sapiens (Human) 
2019-10-23 | PXD015047 | Pride
Val-boropro Card8 Dpp9 
TranscriptomicsActivation of CASP1 induces AML cell pyroptosis and sensitizes to ATRA treatment
Acute myeloid leukemia (AML) is characterized by the accumulation of immature leukemic blasts. The application of all-trans retinoic acid (ATRA) treatments have markedly transformed acute promyelocytic leukemia (APL, the M3 subtype of AML) to a highly manageable disease, and research strategies that...
ORGANISM(S): Homo sapiens 
2024-12-01 | GSE190341 | GEO
UnknownDPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis.
Not available
S-EPMC5477230 | biostudies-literature
UnknownInhibition of Dpp8/9 Activates the Nlrp1b Inflammasome.
Not available
S-EPMC5856610 | biostudies-literature
UnknownA ubiquitin-independent proteasome pathway controls activation of the CARD8 inflammasome.
Not available
S-EPMC9213247 | biostudies-literature
UnknownThe NLRP1 inflammasome: new mechanistic insights and unresolved mysteries.
Not available
S-EPMC6800612 | biostudies-literature
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