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ProteomicsIdentification of CDK9 targets using DRB and quantitative phosphoproteomics
CDK9 is a critical kinase required for the productive transcription of protein-coding genes by RNA polymerase II (pol II) in higher eukaryotes. Phosphorylation of targets including the elongation factor SPT5 and the carboxyl-terminal domain (CTD) of RNA pol II allow the polymerase to pass an early e...
ORGANISM(S): Homo sapiens (Human) 
2022-08-22 | PXD026720 | Pride
Hela Silac Drb Phosphoproteomics Cdk9 
MetabolomicsMetabolomics analysis of Vehicle (DMSO/PBS; (1:1) v/v) and DRB18 (10 mg/kg) treated A549 xenograft tumors
Not available
ORGANISM(S): Mus musculus 
ST001638 | MetabolomicsWorkbench
MetabolomicsControl (DMSO 0.1%; v/v) and 10 µM DRB18 treated A549 lung cancer cells in vitro for 48 hours
Not available
ORGANISM(S): Homo sapiens 
ST001610 | MetabolomicsWorkbench
TranscriptomicsAIM2-responsive genes in colorectal tumor cells
Absent in Melanoma 2 (AIM2) is a member of the HIN-200 family of hematopoietic, IFN-inducible nuclear proteins associated with infection defense and tumor pathology. Recently, AIM2 was found to act as a DNA sensor in innate immunity. In addition, a high frequency of AIM2-alterations was observed in ...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-24155 | biostudies-arrayexpress
TranscriptomicsRate of elongation by RNA polymerase II is influenced by specific gene features and histone modifications
The rate of transcription elongation plays important roles in the timing of expression of full-length transcripts as well as for the regulation of alternative splicing. In this study we coupled Bru-Seq technology with 5,6-dichlorobenzimidazole 1-M-NM-2-D-ribofuranoside (DRB) to estimate the elongati...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-55534 | biostudies-arrayexpress
GenomicsDiscover new allele of HLA DRB*15 in Taiwan
Discover new allele of HLA DRB*15 in Taiwan
PRJEB24622 | ENA
UnknownNew DRB complexes for new DRB functions in plants.
Not available
S-EPMC5731816 | biostudies-literature
Transcriptomics4sUDRB-seq: measuring transcription elongation and initiation genomewide
A new method to measure elongation and intitiation rates Reversal inhibition of transcription with DRB and tagging newly transcribed RNA with 4-thiouridine (4sU)
ORGANISM(S): Homo sapiens 
2014-05-09 | E-GEOD-57116 | biostudies-arrayexpress
TranscriptomicsMapping of nascent RNA upon release of DRB in WT and KD of RECQL5
Global Run-On has been performed on WT or KD for RECQL5 cells after release from DRB. When RECQL5 is knocked-down the transcriptional wave front is more advanced, suggesting that transcription is faster. Constitutive knock-down cell lines expressing or not endogenous levels of shRNA resistant RECQL...
ORGANISM(S): Homo sapiens 
2014-06-09 | E-GEOD-49133 | biostudies-arrayexpress
ModelsStrasen2018 - TGFb SMAD Signalling - DRB treatment
Simulates figure 4H. DRB = 1 simulates the wild type condition and DRB = 0.2 simulates the DRB treated condition.
2024-09-02 | BIOMD0000000997 | BioModels
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