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MetabolomicsAntioxidant Activity, Phytochemical Profiling by UPLC-QTOF-MS, and In Silico Targeting of the RNA-Binding Protein DRBD18 of Trypanosoma brucei by Bioactive Compounds from Tetradenia riparia and Tetracera poggei
Oxidative stress plays a key role in the pathogenesis of African trypanosomiasis, and plant-derived antioxidants represent a promising source of dual-action compounds capable of both scavenging reactive oxygen species and interfering with parasite survival. The present study investigates the antioxi...
2026-09-10 | MTBLS15597 | MetaboLights
ProteomicsProteins interacting with ZC3H28 and DRBD18
ZC3H28 is a zinc-finger domain protein that is essential in bloodstream forms trypanosomes. Tethering ZC3H28 to a reporter mRNA results in an increase of the reporter mRNA levels but without a corresponding increase in protein expression levels. ZC3H28 associates with long RNAs that have low complex...
ORGANISM(S): Trypanosoma brucei 
2022-10-14 | PXD027792 | Pride
Rna-binding proteins  trypanosoma brucei  post-transcriptional regulation 
ProteomicsTranslational control by Trypanosoma brucei DRBD18 contributes to the maintenance of the procyclic state
Trypanosoma brucei occupies distinct niches throughout its life cycle, both within the vertebrate host (fat tissue, bloodstream, central nervous system) and within the insect host, the tsetse fly (taken up with a bloodmeal and passing through the midgut, and migrating to the salivary glands). The im...
ORGANISM(S): Trypanosoma brucei 
2024-01-26 | PXD039064 | Pride
Trypanosoma brucei Drbd18 Ionstar Proteomics 
GenomicsRNAi against DRBD18 in Trypanosoma brucei bloodstream forms
RNAi against DRBD18 in Trypanosoma brucei bloodstream forms
PRJEB41419 | ENA
GenomicsLife stage specific poly(A) site selection regulated by Trypanosoma brucei DRBD18
Life stage specific poly(A) site selection regulated by Trypanosoma brucei DRBD18
PRJNA1076464 | ENA
GenomicsIdentification of target RNAs associated with DRBD18 and its methyl mutants
Identification of target RNAs associated with DRBD18 and its methyl mutants
PRJNA1092083 | ENA
UnknownArginine methylation of DRBD18 differentially impacts its opposing effects on the trypanosome transcriptome.
Not available
S-EPMC4477658 | biostudies-literature
UnknownSelective nuclear export of mRNAs is promoted by DRBD18 in Trypanosoma brucei.
Not available
S-EPMC8460611 | biostudies-literature
TranscriptomicsLife stage specific poly(A) site selection regulated by Trypanosoma brucei DRBD18
In this work, we examine the function of DRBD18 in T. brucei, here using single cell RNA sequencing (scRNAseq) of uninduced and induced DRBD18 knockdowns. In insect procyclic form, we identified one major and one minor population of cells that dramatically increased upon DRBD18 knockdown. Both of th...
ORGANISM(S): Trypanosoma brucei 
2024-07-25 | GSE255758 | GEO
UnknownTranslational control by Trypanosoma brucei DRBD18 contributes to the maintenance of the procyclic state.
Not available
S-EPMC10653379 | biostudies-literature
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