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TranscriptomicsA Methodology for Utilization of Predictive Genomic Signatures in FFPE Samples
Purpose: Gene expression signatures developed to measure the activity of oncogenic signaling pathways have been used to dissect the heterogeneity of tumor samples and to predict sensitivity to various cancer drugs that target components of the relevant pathways, thus potentially identifying therapeu...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-29598 | biostudies-arrayexpress
TranscriptomicsSpecific, Durable and Accurate Gene Expression Signatures of Radiation Response in Mice and Humans
Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. We have sought to determine the impact of several variables on the PB gene expression profile of an environmental exposure, ionizing radiation,...
ORGANISM(S): Mus musculus 
2010-05-17 | E-GEOD-10640 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse transgenic tumors driven by Her or Ras
previously published mouse data; Pubmed IDS: 12754511, 12839964 Experiment Overall Design: see Black, EP, et.al., Cancer Res. 2003 Jul 1;63(13):3716-23 and Huang, E., et.al. Nat Genet. 2003 Jun;34(2):226-30.
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3158 | biostudies-arrayexpress
TranscriptomicsMechanisms of terminal erythroid differentiation defect in EKLF-deficient mice
EKLF is a Krüppel-like transcription factor identified as a transcriptional activator and chromatin modifier in erythroid cells. EKLF-deficient (Eklf -/-) mice die at day 14.5 of gestation from severe anemia. In this study, we demonstrate that early progenitor cells fail to undergo terminal erythroi...
ORGANISM(S): Mus musculus 
2012-03-20 | E-GEOD-36618 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human early stage non-small cell lung carcinoma to refine prognosis for adjuvant therapy
Abstract from paper - Potti A, et al Experiment Overall Design: Retrospective analysis of approximately 200 samples obtained from Duke, ACOSOG and CALGB to develop a Lung metagene predictor that would then be used to assess risk of recurrence and thus identify high risk patients with stage Ia non-sm...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3593 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mammary epithelial cells expressing oncogenes (or GFP control)
Signatures of Oncogenic Pathway Deregulation in Human Cancers; The ability to define cancer subtypes, recurrence of disease, and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Such data is also of substantial importance...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3151 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human growing breast cancer cell lines
Gene expression analysis on growing breast cancer cell lines. Experiment Overall Design: see Bild, A. et.al.
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3156 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast cancers
Signatures of Oncogenic Pathway Deregulation in Human Cancers. The ability to define cancer subtypes, recurrence of disease, and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Such data is also of substantial importance...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3143 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human ovarian cancer samples
Signatures of Oncogenic Pathway Deregulation in Human Cancers. The ability to define cancer subtypes, recurrence of disease, and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Such data is also of substantial importance...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3149 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lung cancers to identify signatures that reflect the activation status of oncogenic pathways
Signatures of Oncogenic Pathway Deregulation in Human Cancers. The ability to define cancer subtypes, recurrence of disease, and response to specific therapies using DNA microarray-based gene expression signatures has been demonstrated in multiple studies. Such data is also of substantial importance...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3141 | biostudies-arrayexpress
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