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ProteomicsVE-PTP inhibition stabilizes endothelial junctions by activating FGD5
Inhibition of VE-PTP, an endothelial receptor type tyrosine phosphatase, triggers phosphorylation of the tyrosine kinase receptor Tie-2, which leads to the suppression of inflammation-induced vascular permeability. Analyzing the underlying mechanism, we show here that inhibition of VE-PTP and activa...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-05-04 | PXD010959 | Pride
Junctions Phosphatase Transmigration Signalling Ve-ptp Lc-msms Fgd5 Shotgun proteomics Inflammation Ptprb Tyrosine kinase receptor Adhesion Phosphorylation Endothelium 
ProteomicsEndothelial EphB4 maintains vascular integrity and transport function in adult heart
Dilated cardiomyopathy is a frequently occurring human disease compromising heart function and a major cause of cardiac death. The causes of cardiomyopathies are often unknown. There is increasing evidence indicating that endothelial cells lining blood vessels control the homeostasis of various orga...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-20 | PXD012575 | Pride
Metabolism Mouse Heart Lc-msms Ephb4 Endothelium Gene expression 
ProteomicsProteomic analysis of mouse oocytes identifies PRMT7 as reprogramming factor that replaces SOX2 in the induction of pluripotent stem cells
The inclusion of oocyte factors together with Yamanaka’s previously identified reprogramming factors (OCT4, SOX2, KLF4 with or without cMYC; OSK(M)) may facilitate the reprogramming process that leads to induced pluripotent stem cells (iPSCs). We previously applied label-free LC-MS/MS analysis to se...
ORGANISM(S): Mus musculus (Mouse) 
2016-05-31 | PXD003093 | Pride
Oocyte Reprogrammome Early embryo Development 
ProteomicsMouse aging oocyte proteome comparison
Here we asked if oocyte proteomes are representative of the transcriptomes, how the abundance of specific genes’ mRNA and protein responds to maternal aging, and if oocyte aging presents the features characteristic of somatic aging. To address these questions on the proteomic level, we employed stab...
ORGANISM(S): Mus musculus (Mouse) 
2016-10-14 | PXD000512 | Pride
Mus musculus Embryonal carcinoma cells Spike-in Silac Oocyte 
TranscriptomicsMaternal age effect on mouse oocytes: new biological insight from proteomic analysis
The long-standing view of 'immortal germ line versus mortal soma' poses a fundamental question in biology concerning how oocytes age in molecular terms. A mainstream hypothesis is that maternal aging of oocytes has its roots in gene transcription. Investigating the proteins resulting from mRNA trans...
ORGANISM(S): Mus musculus 
2014-04-15 | E-GEOD-42959 | biostudies-arrayexpress
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