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ProteomicsThe ubiquitin landscape of the Influenza A Virus polymerase
During influenza A virus (IAV) infections, viral proteins are targeted by cellular E3 ligases for modification with ubiquitin. Here, we decipher and functionally explore the ubiquitin landscape of the IAV polymerase during infection of human alveolar epithelial cells by applying mass spectrometry an...
ORGANISM(S): Homo sapiens (Human) Influenza A virus (A/Wilson-Smith/1933(H1N1)) 
2023-03-11 | PXD030816 | Pride
Influenza a virus Pb1 Affinity enrichment Pa Viral rna-dependent rna polymerase Ubiquitination K-ε-gg motif Lc-msms Pb2 
UnknownAsymmetric Interplay Between K+ and Blocker and Atomistic Parameters From Physiological Experiments Quantify K+ Channel Blocker Release.
Not available
S-EPMC8586521 | biostudies-literature
UnknownA faster and less costly alternative for RNA extraction of SARS-CoV-2 using proteinase k treatment followed by thermal shock.
Not available
S-EPMC7990203 | biostudies-literature
ProteomicsDynarrestin, a novel inhibitor of cytoplasmic dyneins 1 and 2
Aberrant hedgehog (Hh) signaling contributes to the pathogenesis of multiple cancers. Currently available inhibitors target Smoothened, which can acquire mutations causing drug resistance. Thus, compounds that inhibit Hh signaling downstream of Smoothened are urgently needed. We identified dynarrest...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-08 | PXD004440 | Pride
Hedgehog signalling Small molecule inhibitor Dynein Dynarrestin 
ProteomicsMouse aging oocyte proteome comparison
Here we asked if oocyte proteomes are representative of the transcriptomes, how the abundance of specific genes’ mRNA and protein responds to maternal aging, and if oocyte aging presents the features characteristic of somatic aging. To address these questions on the proteomic level, we employed stab...
ORGANISM(S): Mus musculus (Mouse) 
2016-10-14 | PXD000512 | Pride
Mus musculus Embryonal carcinoma cells Spike-in Silac Oocyte 
ProteomicsProximity proteomics of endothelial Weibel-Palade bodies identifies novel regulator of VWF secretion
Weibel-Palade bodies (WPB) are unique secretory organelles of endothelial cells that store factors regulating vascular haemostasis and local inflammation. Endothelial activation triggers the acute exocytosis of WPB, leading to the surface presentation of adhesion molecules relevant for leukocyte rol...
ORGANISM(S): Homo sapiens (Human) 
2019-07-11 | PXD013194 | Pride
Lc-msms Weibel-palade bodies Von-willebrand factor Endothelial cells Proximity labeling Human Biotinylation 
ProteomicsThe footprint of embryonic genome activation on the proteome of mouse preimplantation development
The transformation of a fertilized oocyte into a multicellular embryo comprised of differentiated cells depends on the processing of genetic orders, first in the form of transcripts and then of proteins. Our current understanding of mouse development has greatly benefited from the analysis of transc...
ORGANISM(S): Mus musculus (Mouse) 
2019-10-23 | PXD007082 | Pride
Lc-msms Mouse development Silac Preimplantation Oocyte 
UnknownDoped metal clusters as bimetallic AuCo nanocatalysts: insights into structural dynamics and correlation with catalytic activity by in situ spectroscopy.
Not available
S-EPMC9890489 | biostudies-literature
ProteomicsVE-PTP inhibition stabilizes endothelial junctions by activating FGD5
Inhibition of VE-PTP, an endothelial receptor type tyrosine phosphatase, triggers phosphorylation of the tyrosine kinase receptor Tie-2, which leads to the suppression of inflammation-induced vascular permeability. Analyzing the underlying mechanism, we show here that inhibition of VE-PTP and activa...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-05-04 | PXD010959 | Pride
Junctions Phosphatase Transmigration Signalling Ve-ptp Lc-msms Fgd5 Shotgun proteomics Inflammation Ptprb Tyrosine kinase receptor Adhesion Phosphorylation Endothelium 
TranscriptomicsNKL homeobox gene VENTX is part of a regulatory network in human conventional dendritic cells
Recently, we have documented a hematopoietic NKL-code mapping physiological expression patterns of NKL homeobox genes in human myelopoiesis including monocytes and their derived dendritic cells (DCs). Here, we enlarge this map to include normal NKL homeobox gene expressions in progenitor-derived DCs...
ORGANISM(S): Homo sapiens 
2021-12-01 | E-MTAB-10277 | biostudies-arrayexpress
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