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ProteomicsComparative proteomic landscapes provide insights into mammalian preimplantation development and failure
Understanding mammalian preimplantation development, particularly in humans, at the proteomic level remains limited. Here, we applied our comprehensive solution of ultrasensitive proteomic technology to measure the proteomic profiles of oocytes and early embryos and identified nearly 8,000 proteins ...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-05 | PXD054371 | Pride
Protein turnover Mouse preimplantation development Multi-omics analysis Zygotic genome activation (zga) Ultrasensitive proteomics Cross species analysis 
ProteomicsComparative proteomic landscapes provide insights into mammalian preimplantation development
Proteins play a crucial role in the central dogma as the end product of gene expression. However, a deep proteomic landscape is still the missing puzzle piece of the comprehensive understanding of mammalian preimplantation development. Here, using our recently developed Comprehensive Solution of Ult...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-27 | PXD043363 | Pride
Protein turnover Mouse preimplantation development Multi-omics analysis Zygotic genome activation (zga) Ultrasensitive proteomics Cross species analysis 
TranscriptomicsTranscription profiling of preimplantation mouse embryos to study the requirement of the MAP kinase signaling pathway for preimplantation development.
We examined expression profiles of genes that could be regulated by the MAPK pathways during mouse preimplantation development. We used Affymetrix GeneChips for microarray analysis, and three independent experiments were carried out. 8-cell stage embryos were treated or untreated with MAPK inhibit...
ORGANISM(S): Mus musculus 
2007-09-25 | E-GEOD-2229 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of preimplantation mouse embryo development
Preimplantation mouse embryo development study on Affymetrix MOE430A. Zeng et al (2004) Dev Biol 272:483-496.
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-1744 | biostudies-arrayexpress
Transcriptomicsarray-CGH on single blastomeres from day-4 human preimplantation fresh and frozen embryos
In total, 240 single blastomeres from nine top-quality day-4 embryos frozen at day 3 of development and four fresh top-quality day-4 embryos that had one-cell biopsy on day 3 for preimplantation genetic diagnosis (PGD) were collected. Blastomeres' DNA was amplified using SurePlex DNA Amplification S...
ORGANISM(S): Homo sapiens 
2013-04-05 | E-GEOD-39518 | biostudies-arrayexpress
TranscriptomicsWaves of early transcriptional activation and pluripotency program initiation along human preimplantation development.
The events regulating human preimplantation development are still largely unknown, due to scarcity of material, ethical and legal limitations, and lack of reliable techniques to faithfully amplify the transcriptome of a single cell. Nonetheless, knowledge in human embryology is gathering renewed int...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-29397 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq reveal lineage formation and X-chromosome dosage compensation in human preimplantation embryos
Single-cell RNA-seq of 1,529 cells obtained from 88 human preimplantation embryos ranging from embryonic day 3 to 7.
ORGANISM(S): Homo sapiens 
2016-04-06 | E-MTAB-3929 | biostudies-arrayexpress
ProteomicsMass spectrometry of clinically-discarded preimplantation embryos
Clinically-discarded oocytes and preimplantation embryos at various stages were collected to perform proteome analysis.
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD042633 | Pride
Embryo Homo sapiens 
TranscriptomicsTranscription profiling of mouse preimplantation development
Preimplantation development is a crucial step for successful implantation and pregnancy. Although both compaction and blastocyst formation have been extensively studied, mechanisms regulating early cell division stages before compaction have remained unclear. Here, we show that ERK MAP kinase funct...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7309 | biostudies-arrayexpress
ProteomicsThe footprint of embryonic genome activation on the proteome of mouse preimplantation development
The transformation of a fertilized oocyte into a multicellular embryo comprised of differentiated cells depends on the processing of genetic orders, first in the form of transcripts and then of proteins. Our current understanding of mouse development has greatly benefited from the analysis of transc...
ORGANISM(S): Mus musculus (Mouse) 
2019-10-23 | PXD007082 | Pride
Lc-msms Mouse development Silac Preimplantation Oocyte 
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