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TranscriptomicsExpression profiling in the Drosophila eye reveals unexpected repression of Notch signaling by the JAK/STAT pathway
Although the JAK/STAT pathway regulates numerous processes in vertebrates and invertebrates through modulating transcription, its functionally-relevant transcriptional targets remain largely unknown. With one jak and one stat (stat92E), Drosophila provides a powerful system for finding new JAK/STAT ...
ORGANISM(S): Drosophila melanogaster 
2009-08-01 | E-GEOD-15868 | biostudies-arrayexpress
ProteomicsEye proteome of Drosophila melanogaster
We report the proteome composition of the Drosophila eye – a compound organ that is highly enriched in membrane proteins. The fly eye is a popular model to study the physiology of vision by means of genetic, pharmacological, and dietary interference.While the eye transcriptome and development-relate...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2024-08-09 | PXD044845 | Pride
Eye Gelc-ms/ms Proteomics Drosophila melanogaster 
TranscriptomicsTranscription profiling of Drosophila eye antennal imaginal disc expressing either activated Ras or secreted Spitz
We have used microarrays to identify genes expressed and required for the second mitotic wave (SMW) during eye development. Eye discs expressing Spitz under the control of GMR Gal4 have no SMW as Spitz promotes G1 arrest, ectopic differentiation also occures. To control for the ectopic differentiati...
ORGANISM(S): Drosophila melanogaster 
2008-06-14 | E-GEOD-6300 | biostudies-arrayexpress
MetabolomicsRapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster
Metabolites are active controllers of cellular physiology, but their role in complex behaviors is less clear. Here we report the metabolic changes that occur during the transition between hunger and satiety in Drosophila melanogaster. To analyze these data in the context of fruit fly metabolic netwo...
2019-07-13 | MTBLS180 | MetaboLights
GenomicsGenome-wide binding of the homeodomain transcription factor Sine oculis (So) in the Drosophila eye imaginal disc
We report genome-wide binding of the highly conserved TF Sine oculis (So), which is necessary for Drosophila eye development and has few previously known direct transcriptional targets. Our data identify novel putative targets of So-mediated regulation, including genes involved in multiple aspects o...
ORGANISM(S): Drosophila melanogaster 
2014-03-17 | E-GEOD-52943 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila antennal, eye, leg and wing discs with wild type or eyeless ectopic expression
The discovery of direct downstream targets of transcription factors (TFs) is necessary for understanding the genetic mechanisms underlying complex, highly regulated processes such as development. In this report, we have used a combinatorial strategy to conduct a genome-wide search for novel direct ...
ORGANISM(S): Drosophila melanogaster 
2007-09-28 | E-GEOD-4008 | biostudies-arrayexpress
TranscriptomicsPolycomb repressive complex 2-dependent and M-bM-^@M-^Sindependent functions of Jarid2 in transcriptional regulation in Drosophila [Affymetrix]
Jarid2 was recently identified as an important component of the mammalian Polycomb Repressive Complex 2 (PRC2), where it has a major effect on PRC2 recruitment in mouse embryonic stem cells. Although Jarid2 is conserved in Drosophila, it has not previously been implicated in Polycomb (Pc) regulation...
ORGANISM(S): Drosophila melanogaster 
2012-02-23 | E-GEOD-36038 | biostudies-arrayexpress
GenomicsThe BTB-zinc finger transcription factor Abrupt acts as an epithelial oncogene in Drosophila through maintaining a progenitor-like cell state
The capacity of tumor cells to maintain continual overgrowth potential has been linked to the commandeering of normal self-renewal pathways. Using an epithelial cancer model in Drosophila we carried out an overexpression screen for oncogenes capable of cooperating with the loss of the epithelial api...
ORGANISM(S): Drosophila melanogaster 
2013-08-15 | E-GEOD-42928 | biostudies-arrayexpress
ProteomicsDrosophila melanogaster eye Proteomics
Absolute (molar) quantification determines proteins stoichiometry in complexes, networks and metabolic pathways. We employed MS Western workflow to determine molar abundances of proteins critical for morphogenesis and phototransduction (PT) in eyes of Drosophila melanogaster using a single chimeric ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2020-07-19 | PXD018001 | Pride
Qconcat Drosophila 
TranscriptomicsExpression data from third instar Drosophila eye discs
Third instar larval eye discs provide an in vivo model for cell cycle exit studies. Posterior to the Second Mitotic Wave proliferation is absent in a wild type eye disc. Inactivating mutations in tumor suppressor-like genes can lead to genome wide changes in gene expression that allow for inapprop...
ORGANISM(S): Drosophila melanogaster 
2011-02-22 | E-GEOD-24978 | biostudies-arrayexpress
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