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MetabolomicsMechanisms of Etomidate Addiction and Neuro-Hepatic Toxicity: Molecular Pathway Analysis Based on Multi-Omics Integration
Etomidate has been linked to addictive behaviors and neurotoxic and hepatotoxic effects. We established a mouse exposure model across graded etomidate doses and assessed reward using conditioned place preference (CPP). Proteomic and metabolomic profiling of cerebral tissue and right hepatic lobe tis...
2026-09-02 | MTBLS15524 | MetaboLights
MetabolomicsMechanisms of Etomidate Addiction and Neuro-Hepatic Toxicity: Molecular Pathway Analysis Based on Multi-Omics Integration
Etomidate has been linked to addictive behaviors and neurotoxic and hepatotoxic effects. We established a mouse exposure model across graded etomidate doses and assessed reward using conditioned place preference (CPP). Proteomic and metabolomic profiling of cerebral tissue and right hepatic lobe tis...
2026-09-02 | MTBLS15525 | MetaboLights
GenomicsStabilized biological production by product addiction
Populations of engineered metabolite-producing microorganisms are prone to evolutionary production declines during industrial-scale cultivations. In this study, we develop a synthetic product addiction system in E coli that addicts mevalonic acid production cells to mevalonic acid. Through experimen...
ORGANISM(S): Escherichia coli K-12 
2018-02-09 | E-MTAB-6182 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat brain tissues from animals with varying levels of access to cocaine
By using high-density oligonucleotide arrays, we profiled gene expression in reward-related brain regions of rats that developed escalated cocaine intake after extended access to cocaine (6 h per day). Rats allowed restricted daily access to cocaine (only 1 h) that displayed a stable level of cocain...
ORGANISM(S): Rattus norvegicus 
2007-10-10 | E-GEOD-3016 | biostudies-arrayexpress
UnknownExtended access to fentanyl vapor self-administration leads to addiction-like behaviors in mice: Blood chemokine/cytokine levels as potential biomarkers.
Not available
S-EPMC9851134 | biostudies-literature
TranscriptomicsTranscriptional profiles of psychostimulant reinforcement in rats
Drug-induced alterations in transcriptional regulation play a central role in establishing the persistent neuroplasticities that occur during drug addiction. Additionally, changes in gene expression associated with drug administration provide valuable insight into the molecular basis of drug abuse. ...
ORGANISM(S): Rattus norvegicus 
2013-06-27 | E-GEOD-43748 | biostudies-arrayexpress
TranscriptomicsmiRNA expression signatures for human stomach biopsy samples, H. pylori positive versus negative
We have employed whole microRNA microarray with the potential to distinguish H.pylori infection.Among the 470 human miRNAs represented on the array chip, 228 were undetectable or expressed below the background and so were eliminated, leaving 242 miRNAs for the supervised analysis. When comparing 10 ...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-19769 | biostudies-arrayexpress
UnknownSimulating the impact of Addiction Consult Services in the context of drug supply contamination, hospitalizations, and drug-related mortality.
Not available
S-EPMC8810590 | biostudies-literature
UnknownReceipt of addiction treatment as a consequence of a brief intervention for drug use in primary care: a randomized trial.
Not available
S-EPMC5382041 | biostudies-literature
UnknownHypothalamic response to cocaine cues and cocaine addiction severity.
Not available
S-EPMC6453736 | biostudies-literature
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