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MetabolomicsClinical Application Value of Ceramide and Sphingomyelin as Biomarkers for the Diagnosis of Drug-Induced Liver Injury

Background : Drug-induced liver injury (DILI) is a serious health concern that presents challenges in early detection and accurate diagnosis, thereby complicating the treatment of this liver disease. Therefore, it is crucial to explore specific biomarkers to improve the accuracy of diagnosing DIL...

2025-07-23 | MTBLS12765 | MetaboLights
ProteomicsMinimizing Taxonomic and Natural Product Redundancy in Microbial Libraries Using MALDI-TOF MS and the Bioinformatics Pipeline IDBac
This bacterial MALDI-TOF dataset was used for the study "AMinimizing Taxonomic and Natural Product Redundancy in Microbial Libraries Using MALDI-TOF MS and the Bioinformatics Pipeline IDBac" It consists of triplicate MALDI-TOF MS profiles (both reflectron and linear datasets) for >1,600 bacteria cu...
ORGANISM(S): Multiple 
2019-02-18 | MSV000083461 | MassIVE
UnknownImpact of mixing and shaking on mRNA-LNP drug product quality characteristics.
Not available
S-EPMC11343734 | biostudies-literature
ProteomicsA Sensitive, Rapid, Robust and Reproducible Workflow for Host Cell Protein Profiling in Biopharmaceutical Process Development
There is a growing industry and regulatory need to detect host cell protein (HCP) impurities in the production of protein biopharmaceuticals, as certain HCPs can impact product stability, safety, and efficacy, even at low levels.1-6 In some cases, regulatory agencies require the identification as we...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-02 | PXD018427 | Pride
Monoclonal antibody (mab) Drug product (dp) Evosepone Drug substance (ds) Host cell proteins (hcps) Lc-ms/ms 
ProteomicsMAM Nature Protocol 2022-chimeric IgG1mAb DP
Peptide mapping experiment on a chimeric IgG1 mAb drug product (three replicates are provided as 1, 2 and 3)
ORGANISM(S): Igg1 Monoclonal Antibody 
2022-02-03 | MSV000088774 | MassIVE
TranscriptomicsRNAseq of A375 melanoma cells and A375 with ARID1A KO in control conditions and treatment with trametinib, vemurafenib or combination
The experiment aimed to study mechanisms of melanoma drug resistance. ARID1A confers resistance to trametinib and therefore RNAseq was collected alongside other omics data for parental A375 likes, and A375 lines with ARID1A KO, in the presence of no drug, trametinib, vemurafenib or their combination
ORGANISM(S): Homo sapiens 
2025-02-18 | E-MTAB-14759 | biostudies-arrayexpress
ProteomicsTarget Landscape of Clinical Kinase Inhibitors
Here, we provide a comprehensive overview of the selectivity profiles of 242 kinase inhibitors currently in clinical trials. We screened available inhibitors against human protein kinases by using the Kinobead technology resulting in a drug matrix identifying the druggable kinome and related protein...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-01-12 | MSV000081932 | MassIVE
TranscriptomicsTranscription profiling of Salmonella enterica serovar Typhimurium exposure to triclosan
S. Typhimurium SL1344 was exposed to the minimum inhibitory concentration of triclosan and the transcriptomic response analysed.
ORGANISM(S): Salmonella enterica 
2009-08-28 | E-MEXP-2078 | biostudies-arrayexpress
ProteomicsMAM Nature Protocol 2022-chimeric IgG1mAb DP spiked with HCPs
Peptide mapping experiment on chimeric Ig1 mAb drug product spiked with spiked with different levels of HCPs, cathepsin and rHLPL, at 3 different levels, 10, 100, and 1000ppm (three replicates are provided for each spiked level as 1, 2, and 3)
ORGANISM(S): Igg1 Monoclonal Antibody 
2022-02-03 | MSV000088775 | MassIVE
UnknownIdentification, Synthesis, and Characterization of N-Formyl Mirabegron: A New Degradation Product Formed by Formic Acid Impurity in Pharmaceutical Excipients.
Not available
S-EPMC11651750 | biostudies-literature
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