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GenomicsRNA-Seq of Primary and Recurrent DSRCT Tumors
RNA-Seq of Primary and Recurrent DSRCT Tumors
PRJNA961835 | ENA
GenomicsProteomic Comparison Of DSRCT, Normal Mesenteric Tissues and ES
Proteomic Comparison Of DSRCT, Normal Mesenteric Tissues and ES
PRJNA428300 | ENA
TranscriptomicsEWS-WT1 Oncogene Activates a Neuronal Reprogramming Factor ASCL1 and Mediates Partial Neural Differentiation
A chromosomal translocation fusion gene product EWS-WT1 is the defining genetic event in Desmoplastic Small Round Cell Tumor (DSRCT), a rare but aggressive tumor with a high rate of mortality. EWS-WT1 oncogene acts as an aberrant transcription factor that drives tumorigenesis, but the mechanism by w...
ORGANISM(S): Mus musculus 
2014-09-11 | E-GEOD-53301 | biostudies-arrayexpress
GenomicsN3 induced reprogramming and ShWT1 knock-down in DSRCT cell lines
N3 induced reprogramming and ShWT1 knock-down in DSRCT cell lines
PRJNA746313 | ENA
GenomicsDSRCT RNA genomic sequencing
Purpose: To further understand the molecular pathogenesis of desmoplastic small round cell tumor (DSRCT), a rare but often fatal malignancy occurring primarily in young males, we used next-generation RNA sequencing to investigate the gene expression profiles intrinsic to this disease.Experimental De...
EGAS00001002770 | EGA
GenomicsRNA-seq data of JN and BER-DSRCT dox inducible shSIK1 cell lines
RNA-seq data of JN and BER-DSRCT dox inducible shSIK1 cell lines
PRJNA809549 | ENA
TranscriptomicsWhole genome transcription profiling of the JN-DSCRT1 cell line treated with Trabectedin
The purpose of experiments consisted in studying the mode of action of Trabectedin in Desmoplastic Small Round Cell Tumor (DSRCT). In order to investigate the effects of Trabectedin in the expression of EWS-WT1 target genes in relation to the drug growth inhibitory effect, the JN-DSCRT-1 cell line w...
ORGANISM(S): Homo sapiens 
2017-01-27 | E-MTAB-4532 | biostudies-arrayexpress
ProteomicsSuper-enhancer-driven CACNA2D2 is an EWSR1::WT1 signature gene encoding a diagnostic marker for desmoplastic small round cell tumor (DSRCT)
Desmoplastic small round cell tumor (DSRCT) is a highly aggressive cancer predominantly occurring in young male adolescents. It mainly arises at sites lined by mesothelium, such as the abdominal cavity, and is driven by the pathognomonic EWSR1::WT1 fusion oncoprotein. The dismal survival rates (5–20...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD053786 | Pride
Super-enhancer Dsrct Proteomics Scrna-seq Cacna2d2 Ewsr1::wt1 Ihc Biomarker 
UnknownEWSR1-WT1 Target Genes and Therapeutic Options Identified in a Novel DSRCT In Vitro Model.
Not available
S-EPMC8657306 | biostudies-literature
TranscriptomicsRNA-Seq of Primary and Recurrent DSRCT Tumors
Desmoplastic small round cell tumor (DSRCT) is a rare pediatric cancer caused by the EWSR1-WT1 fusion oncogene. Despite initial response to chemotherapy, DSRCT has a recurrence rate of over 80% leading to poor patient prognosis with a 5-year survival rate of only 15-25%. Owing to the rarity of DSRCT...
ORGANISM(S): Homo sapiens 
2023-07-19 | GSE230603 | GEO
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