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Osimertinib is the first-line therapy for EGFR-mutated non-small cell lung cancer, but acquired resistance commonly develops, linked to a drug-tolerant persister (DTP) cell state that promotes survival and eventual resistance. Using data-independent acquisition mass spectrometry (DIA-MS), we mapped ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD058009 | Pride
Drug tolerant persister (DTP) cells enter into a reversible slow-cycling state after cancer drug treatment. These cells are the living proof of response to a drug, and an interesting experimental subject for biomarker discovery. Here, we performed proteomic characterization of the breast cancer (BC)...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD034037 | Pride
Single-cell analysis of Diphtheria, Tetanus, and Pertussis (DTP)-vaccinated repertoire
We present here a new expression profiling study of the 60 cell lines of the National Cancer Institute (NCI) Developmental Therapeutics program (DTP) drug screen (NCI-60) using the 41,000-probe Agilent Whole Human Genome Oligo Microarray. The expression levels of ∼21,000 genes were measured. The pr...
ORGANISM(S): Homo sapiens 
Photosensitizer DTP Co-Administered with Statins Potentiates Renal Carcinoma Therapy by Modulating Cholesterol to Enhance PDT.
Diphtheria, tetanus, and pertussis (DTP) are infectious diseases caused by toxin-producing bacteria that can be fatal, especially in children. Despite the availability of combined DTP vaccines for more than 60 years, a comprehensive understanding of how human antibodies respond to DTP vaccination, w...
ORGANISM(S): Homo sapiens 
2023-09-30 | GSE238120 | GEO
we examined the label-free proteomics in untreated LNCaP (NC), DTP-ENZ, R5-ENZ, R10-ENZ, R20-ENZ, DTP-EPI, R5-EPI, R10-EPI, and R20-EPI groups by nanoscale liquid chromatography coupled to tandem mass spectrometry (nanoLC-MS/MS). The groups each with three biological replicates were used for proteom...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD032983 | Pride
Observational studies from low-income countries have shown that the vaccination against diphtheria, tetanus and pertussis (DTP) is associated with excess female mortality due to infectious diseases. To investigate possible changes in gene expression after DTP vaccination, we identified a group of ni...
ORGANISM(S): Homo sapiens 
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