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This study aimed to investigate the anxiolytic effects of GABA administration and its underlying molecular mechanisms in a chronic restraint stress (CRS)-induced anxiety model in C57BL/6J mice. CRS mice were established by placing the animals in well-ventilated 50 ml centrifuge tubes for 2 hours dai...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD059153 | Pride
Major depressive disorder (MDD) is a common disease affecting 300 million people worldwide. The existing drugs are ineffective for approximately 30% of patients, so it is urgent to develop new antidepressant drugs with novel mechanisms. Here, we found that norisoboldine (NOR) showed an antidepressan...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD047064 | Pride
Aberrant activation of FGFR3 via overexpression or mutation is a frequent feature of bladder cancer; however, its molecular and cellular consequences and functional relevance to carcinogenesis are not well understood. In this study with a bladder carcinoma cell line expressing inducible FGFR3 shRNA...
ORGANISM(S): Homo sapiens 
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