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MetabolomicsProduction of chain-extended cinnamoyl compounds by overexpressing two adjacent cluster-situated LuxR regulators in Streptomyces globisporus C-1027

Natural products from microorganisms are important sources for drug discovery. With the development of high-throughput sequencing technology and bioinformatics, a large amount of uncharacterized biosynthetic gene clusters (BGCs) in microorganisms have been found, which show the potential for nove...

2023-09-06 | MTBLS5152 | MetaboLights
TranscriptomicsHuman Hepatocytes with Drug Metabolic Function Induced from Fibroblasts by Lineage Reprogramming
We generated induced human hepatocyte by transduction of several lineage specific transcription factors and analyzed the gene expression profile of generated hepatocytes and freshly isolated human hepatocytes through RNA sequencing. Global gene expression profile analysis
ORGANISM(S): Homo sapiens 
2014-03-10 | E-GEOD-54066 | biostudies-arrayexpress
ProteomicsPersulfidation alters gene regulatory programs and promotes endothelial specification
Endogenously generated sulfides are conserved among species and tissues and exert multiple effects through diverse mechanisms. Although sulfides have been linked to cell fates, their role in pluripotent stem cell commitment remains unknown. Here we discovered that during directed differentiation of ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-29 | PXD071015 | Pride
Sulfide supplementation Endothelial commitment Persulfidation Stem cells 
UnknownPersulfidation alters gene regulatory programs and promotes endothelial specification.
Not available
S-EPMC12721145 | biostudies-literature
ProteomicsDeep Profiling of the Human Plasma Proteome with Surface-Functionalized Molybdenum Disulfide Nanomaterials
Here, we report the synthesis and characterization of surface-functionalized magnetic molybdenum disulfide (MoS2) for the large-scale enrichment of low abundant plasma proteins and deep profiling by mass spectrometry.
ORGANISM(S): Homo Sapiens Escherichia Coli 
2022-09-15 | PXD036756 |
ProteomicsTandem Enrichment and Simultaneous Profeling
Tandem Enrichment and Simultaneous Profeling of N-glycopeptides and phosphopeptides
ORGANISM(S): Homo Sapiens 
2022-04-18 | PXD033282 |
ProteomicsProteomics analysis reveals novel insights into the mechanism of hepatotoxicity induced by Tripterygium Wilfordii multiglycoside in mice
Tripterygium wilfordii multiglycoside (GTW), extracted and purified from the peeled roots of Tripterygium wilfordii Hook.f. (TwHF), is a well-known traditional Chinese medicine and applied to various autoimmune diseases clinically. However, it has been reported to cause severe liver injury. At prese...
ORGANISM(S): Mus Musculus 
2022-11-10 | PXD038084 |
ProteomicsStructure-guided development of chemically tailored peptide binders of RNF43/ZNRF3 to enable versatile design of membrane protein-targeting PROTACs
Targeted membrane protein degradation using cell surface E3 ligases RNF43/ZNRF3 via proteolysis targeting chimeras (PROTACs) represents an effective strategy for treating membrane drug targets that cannot be fully inhibited using traditional inhibitors. Several ingenious chimeras have been developed...
ORGANISM(S): Homo Sapiens 
2025-03-04 | PXD061425 |
ProteomicsProteomic IP-MS analysis of Asprosin/PFKP in regulating cardiac hypertrophy model
This dataset contains two parts of proteomics data: a) the identification and analysis results of co-immunoprecipitation (Co-IP: Flag-asprosin/HA-PFKP) in cardiomyocytes overexpressing Flag-asprosin/HA-PFKP; b) the identification and analysis results of co-immunoprecipitation (Co-IP) using IgG as a ...
ORGANISM(S): Mus Musculus 
2025-12-24 | PXD072385 |
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