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ProteomicsMAP2Ks can activate MAP kinases using ADP in vitro
Kinases are a diverse group of enzymes that use ATP to phosphorylate a variety of substrates. Protein kinases evolved in eukaryotes as important mediators of cell signalling that target specific amino acid side chains to modulate downstream protein function. Among them, the MAPKs (mitogen-activated ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2025-09-29 | PXD065314 | Pride
Kinase Adp Phosphorylation Mapk 
UnknownDual-specificity mitogen-activated protein kinase kinases can use ADP to phosphorylate MAP kinases invitro.
Not available
S-EPMC12446509 | biostudies-literature
UnknownDual-Specificity, Tyrosine Phosphorylation-Regulated Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview.
Not available
S-EPMC8199962 | biostudies-literature
GenomicsMethylation of Dual Specificity Phosphatase 4 Controls Cell Differentiation
Methylation of Dual Specificity Phosphatase 4 Controls Cell Differentiation
PRJNA729047 | ENA
UnknownDynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling.
Not available
S-EPMC6539644 | biostudies-literature
ProteomicsContext-dependent regulatory mechanisms control site-specific information processing within the MEK/ERK module
The impact of the cellular context and receptor type on the dynamics of phosphorylation cycles in signaling pathways are unclear. We employ an unbiased approach to identify network alterations that explain phosphorylation dynamics of the MEK/ERK module in response to hepatocyte growth factor or inte...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080803 | MassIVE
TranscriptomicsTranscription profiling of spleens from dual specificity phosphatase-1 (DUSP1) deficient and wild type mice to demonstrate a specific regulatory role of DUSP1 on a subset of LPS-induced genes that control the outcome of endotoxin shock.
Activation of the Mitogen activated protein kinase (MAPK) cascade following Toll-like receptor (TLR) stimulation enables innate immune cells to rapidly activate cytokine gene expression. A balanced response to signals of infectious danger requires that cellular activation is transient. Here, we iden...
ORGANISM(S): Mus musculus 
2007-11-01 | E-GEOD-3565 | biostudies-arrayexpress
ProteomicsDYRK1A, a potential therapeutic target for head and neck squamous cell carcinoma
To identify the activated tyrosine kinase signaling pathways in HNSCC, we carried out phosphotyrosine profiling using a panel of HNSCC cell lines compared to a normal oral keratinocyte. A total of 61 unique phosphosites were identified across these cell lines. Dual-specificity tyrosine-(Y)-phosphor...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002132 | Pride
Dual specificity kinases Head and neck squamous cell carcinoma Phosphoproteomics 
GenomicsDual specificity phosphatase 6 (DUSP6) deletion protects mice and reduces disease severity in autoimmune arthritis.
Dual specificity phosphatase 6 (DUSP6) deletion protects mice and reduces disease severity in autoimmune arthritis.
PRJNA1115144 | ENA
MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
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