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ProteomicsElucidation of B-cell specific drug immunogenicity liabilities via a novel ex vivo assay
The appended raw files, csv files and other documents were deposited in the public domain in support for the publication "Elucidation of B-cell specific drug immunogenicity liabilities via a novel ex vivo assay" by Cary M Looney, Axel Ducret, Guido Steiner, Karen Dernick, Katharina Hartman, Michel S...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-02-19 | MSV000097151 | MassIVE
ProteomicsInternalization of therapeutic antibodies into Dendritic cells as a risk factor for immunogenicity
The appended raw files, csv files and other documents were deposited into the public domain in support for the publication "Internalization of therapeutic antibodies into Dendritic cells as a risk factor for immunogenicity" by Michel Siegel, Anna-Lena Bolender, Axel Ducret, Johannes Fraidling, Katha...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-26 | MSV000095695 | MassIVE
ProteomicsExpanding the MAPPs assay to accommodate MHC-II pan re-ceptors for improved predictability of potential T cell epitopes
The appended raw files, csv files and other documents were deposited in the public domain in support for the publication "Expanding the MAPPs assay to accommodate MHC-II pan re-ceptors for improved predictability of potential T cell epitopes" by Katharina Hartman, Guido Steiner, Michel Siegel, Cary ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-25 | MSV000092747 | MassIVE
ProteomicsMouse heart toxicity - A Novel Positron Emission Tomography (PET) Approach to Monitor Cardiac Metabolic Pathway Remodeling in Response to Sunitinib Malate
Background Sunitinib is a small molecule tyrosine kinase inhibitor approved for the treatment of diverse cancers. Despite widespread clinical approval the associated cardiovascular toxicity sequelae are of concern; high grade toxicities may lead to dose reduction, interruption or discontinuation. Th...
ORGANISM(S): Mus musculus (Mouse) 
2017-01-03 | PXD001888 | Pride
Mouse Heart tissue Lc-ms/ms 
Proteomicscell surface glycoproteome liver and lung
Purpose Cell surface proteins are the primary means for a cell to sense and interact with its environment and their dysregulation has been linked to numerous diseases. In particular, the identification of proteins specific to a single tissue type or to a given disease phenotype may enable the charac...
ORGANISM(S): Homo sapiens (Human) 
2015-07-22 | PXD001988 | Pride
Ltq-orbitrap Glycocapture Lc-ms Epithelial lung cells Human Primary hepatocytes 
ProteomicsDevelopment and qualification of a dendritic cell internalization assay contributing to the immunogenicity risk evaluation of biotherapeutics
The appended raw files, csv files and other documents were deposited into the public domain in support for the publication "Development and characterization of a dendritic cell internalization assay contributing to the immunogenicity risk evaluation of biotherapeutics" by Michel Siegel, Aman Padamse...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-12 | MSV000095578 | MassIVE
ProteomicsEnabling Routine MHC-II Associated Peptide ProteomicS (MAPPs) for Risk Assessment of Drug-Induced Immunogenicity
The appended raw files, csv files and other documents were deposited in the public domain in support for the publication Enabling Routine MHC-II Associated Peptide ProteomicS (MAPPs) for Risk Assessment of Drug-Induced Immunogenicity Guido Steiner, Celine Marban-Doran, Jessica Langer, Tatiana Pimeno...
ORGANISM(S): Custom Antibody Sequences Homo Sapiens (ncbitaxon:9606) 
2020-05-05 | MSV000085375 | MassIVE
ProteomicsIdentification of HER2 peptides for quantification in formalin-fixed paraffin-embedded breast cancer tissues
The ability to accurately quantify proteins in formalin-fixed paraffin-embedded (FFPE) tissues using targeted mass spectrometry opens exciting perspectives for biomarker discovery. We have developed and evaluated a selected reaction monitoring (SRM) assay for the human receptor tyrosine-protein kina...
ORGANISM(S): Homo sapiens (Human) 
2015-07-16 | PXD002281 | Pride
Breast cancer Human receptor tyrosine-protein kinase erbb-2 (her2) Human Ltq orbitrap velos Formalin-fixed parrafin-embedded tissues (ffpe) 
ProteomicsBiomarker Discovery in FFPE tissues by SRM
The identification of clinically relevant biomarkers represents an important challenge in oncology. This can be addressed with biomarker discovery studies in formalin-fixed paraffin-embedded (FFPE) tissues. However, reliably measuring large sets of proteins in FFPE tissues remains challenging. Here ...
ORGANISM(S): Homo Sapiens 
2022-09-25 | PXD025135 | panorama
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