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ProteomicsDelineating the Rb1 interactome data and its modulations during cell cycle progression.
The retinoblastoma (Rb) protein is a potent tumor suppressor which is known to negatively regulate the cell cycle as well as tumor progression. Phosphorylated Rb protein (pRb) has been demonstrated to be in-charge for the key G1 checkpoint, blocking entry into S-phase and thereby the cell growth. Th...
ORGANISM(S): Homo sapiens (Human) 
2017-09-14 | PXD007708 | Pride
Rb1 Ap-ms Silac Interactome Tumor suppressor Cell cycle 
ProteomicsDefining the Akt1 interactome and delineating alterations in its composition as a function of cell cycle progression.
Akt1 expressing Hek 293 cells were SILAC labeled to capture dynamic changes in Akt1 interactome as the cell cycle progresses from G0 to G1S and then G2 phase. This will help in understanding how Akt1 extends its regulatory effect upon cell cycle progression.
ORGANISM(S): Homo sapiens (Human) 
2017-01-16 | PXD005557 | Pride
Ap-ms Silac Akt1 Cell cycle Interactome 
ProteomicsDelineating changing partners of Akt1 protein as a function of its active state in HEK-293 Cells
Akt1 is a multi-functional protein, implicated and activated in multiple human solid tumors. Functional diversity of Akt1 is a result of its interactions with other proteins; which changes with changing context. This study was designed to capture the dynamics of Akt1 Interactome as a function of its...
ORGANISM(S): Homo sapiens (Human) 
2017-03-02 | PXD005976 | Pride
Apms Silac Akt1 Interactome 
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