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ProteomicsPreclinical Optimization of the PI3K/Akt inhibitor Paxalisib for the Treatment of Diffuse Midline Glioma
Diffuse midline glioma (DMG) is a uniformly fatal pediatric, adolescent, and young adult cancer diagnosed in the midline structures of the brain. PI3K/Akt signaling is an overarching contributor to the poor outcomes of DMG patients due to their dependance on insulin and recurring mutations and ampli...
ORGANISM(S): Homo sapiens (Human) 
2024-02-20 | PXD036114 | Pride
Phosphoproteomics Dmg Proteogenomics Dipg Pi3k/akt Paxalisib 
UnknownDeciphering the Genetic Basis of Root and Biomass Traits in Rapeseed (Brassica napus L.) through the Integration of GWAS and RNA-Seq under Nitrogen Stress.
Not available
S-EPMC9323118 | biostudies-literature
ProteomicsSynergistic targeting of DNA-PK and KIT signaling pathways in KIT mutant acute myeloid leukemia
Acute Myeloid Leukemia (AML) is the most common and aggressive form of acute leukemia, with a 5-year survival rate of just 24%. Over a third of all AML patients harbor activating mutations in kinases, such as the receptor tyrosine kinases FLT3 and KIT. FLT3 and KIT mutations are associated with poor...
ORGANISM(S): Mus Musculus 
2023-01-26 | PXD030214 | panorama
ProteomicsDynamic Landscape of Extracellular Vesicle-Associated Proteins Is Related to Treatment Response of Patients with Metastatic Breast Cancer
Breast cancer is the leading cause of cancer death in women. The majority of these deaths are due to disease metastasis, in which cancer cells disseminate to multiple organs and disrupt vital physi-ological functions. It is widely accepted that breast cancer cells secrete extracellular vesicles (EVs...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-27 | MSV000087527 | MassIVE
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