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TranscriptomicsAffymetrix SNP array data for Diffuse Intrinsic Pontine Glioma
Diffuse intrinsic pontine glioma (DIPG) is one of the most devastating of paediatric malignancies and one for which no effective therapy exists. A major contributor to the failure of therapeutic trials is the assumption that biologic properties of brainstem tumours in children are identical to cereb...
ORGANISM(S): Homo sapiens 
2010-06-16 | E-GEOD-18828 | biostudies-arrayexpress
TranscriptomicsRNA-seq in HSJD-DIPG-007 cells treated with JQ1, ICG-001, JQ1 and ICG-001 and DMSO as control.
This study aims to characterize gene expression changes upon treatment with JQ1, ICG-001, and combined treatment. The general goal is to identify the mechanism for high efficacy of combinatorial treatment of BET and CBP inhibition in DIPG cells.
ORGANISM(S): Homo sapiens 
2020-08-01 | E-MTAB-8243 | biostudies-arrayexpress
TranscriptomicsGenome-wide Analyses of Diffuse Intrinsic Pontine Gliomas
Purpose: More than 90% of children with diffuse intrinsic pontine glioma (DIPG) die within 2 years of diagnosis. There is a dire need to identify therapeutic targets, however lack of patient material for research has limited progress. We evaluated a large cohort of diffuse intrinsic pontine gliomas ...
ORGANISM(S): Homo sapiens 
2011-09-20 | E-GEOD-26576 | biostudies-arrayexpress
ProteomicsProteome of SUDIPG, SF7761 and primary non diseased brain samples
DIPG is a paediatric brainstem glioma with no cure. Cellular immunotherapy approaches require specific targeting of unique and tumour specific cell surface antigens, however, there is a paucity of known targets for DIPG. In this study we have used a proteomics approach to interrogate an array of pat...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD038372 | Pride
Brain Bruker Dipg Proteomics S-trap Dda 
GenomicsChIP-seq of H3K27ac and H3K27me3 in HSJD-DIPG-007 cell line
Identification of super enhancer regions in the HSJD-DIPG-007 cell line and the associated genes with these regions. This study aims to evaluate the efficacy of combined use of BET and CBP inhibition in DIPG.
ORGANISM(S): Homo sapiens 
2020-08-01 | E-MTAB-8242 | biostudies-arrayexpress
TranscriptomicsChIP-seq of H3K27ac and H3K27me3 in HSJD-DIPG-007 cell line upon treatment with ICG-001 and JQ1
Identification of super enhancer regions in the HSJD-DIPG-007 cell line and the associated genes with these regions. This study aims to evaluate the efficacy of combined use of BET and CBP inhibition in DIPG.
ORGANISM(S): Homo sapiens 
2020-08-01 | E-MTAB-9152 | biostudies-arrayexpress
ProteomicsThe immunopeptidome and proteome of DIPG
DIPG is a devastating paediatric and young adult brainstem tumour with no cure and a median overall survival of 9 months. Cellular immunotherapy approaches require specific targeting of unique and tumour specific cell surface antigens, however, there is a paucity of known targets for DIPG. Here we u...
ORGANISM(S): Homo sapiens (Human) 
2023-09-25 | PXD038271 | Pride
Hla Proteomics Dipg Immunopeptidomics 
UnknownAccuracy of central neuro-imaging review of DIPG compared with histopathology in the International DIPG Registry.
Not available
S-EPMC9071293 | biostudies-literature
ProteomicsHuman diffuse intrinsic pontine glioma (DIPG) LC-MSMS
Diffuse intrinsic pontine glioma (DIPG), a lethal pediatric cancer driven by H3K27M oncohistones, exhibits aberrant epigenetic regulation and stem-like cell states. Here, we uncover an axis involving H3.3K27M oncohistones, CREB5/ID1, which sustains the stem-like state of DIPG cells, promoting malign...
ORGANISM(S): Homo sapiens (Human) 
2025-01-28 | PXD053094 | Pride
Human Dipg cell lines Ip-ms 
ProteomicsHuman diffuse intrinsic pontine glioma (DIPG) LC-MSMS
Diffuse intrinsic pontine glioma (DIPG), a lethal pediatric cancer driven by H3K27M oncohistones, exhibits aberrant epigenetic regulation and stem-like cell states. Here, we uncover an axis involving H3.3K27M oncohistones, CREB5/ID1, which sustains the stem-like state of DIPG cells, promoting malign...
ORGANISM(S): Homo sapiens (Human) 
2025-01-28 | PXD060271 | Pride
Human Dipg cell lines Ip-ms 
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