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ProteomicsMDR1 Drug Efflux Pump Promotes Acquired and Intrinsic Resistance to Protein Degraders in Cancer Cells
PROTACs (Proteolysis-Targeting Chimeras) represent a revolutionary new class of drugs that selectively degrade proteins of interest from cells. PROTACs targeting oncogenes are avidly being explored for cancer therapies, with several currently in clinical trials. Drug resistance represents a signif...
ORGANISM(S): Homo sapiens (Human) 
2022-10-06 | PXD029233 | Pride
Mdr1 Degrader Cancer Protac Drug resistance Abcb1 
Metabolomics1H NMR Metabolomics Identifies Underlying Inflammatory Pathology in Osteoarthritis and Rheumatoid Arthritis Synovial Joints
Despite osteoarthritis (OA) and rheumatoid arthritis (RA) being typically age-related, their underlying etiologies are markedly different. We used 1H nuclear magnetic resonance (NMR) spectroscopy to identify differences in metabolite profiles in low volumes of OA and RA synovial fluid (SF). SF was a...
2018-10-11 | MTBLS564 | MetaboLights
UnknownCombining physical therapy and cognitive behavioral therapy techniques to improve balance confidence and community participation in people with unilateral transtibial amputation who use lower limb prostheses: a study protocol for a randomized sham-control clinical trial.
Not available
S-EPMC6937857 | biostudies-literature
UnknownKinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.
Not available
S-EPMC3694067 | biostudies-literature
UnknownPhysician perceptions and practice patterns regarding fertility preservation in hematopoietic cell transplant recipients.
Not available
S-EPMC3914209 | biostudies-literature
UnknownEGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis.
Not available
S-EPMC4151226 | biostudies-literature
UnknownBiallelic Variants in OTUD6B Cause an Intellectual Disability Syndrome Associated with Seizures and Dysmorphic Features.
Not available
S-EPMC5384096 | biostudies-literature
UnknownAge-related reduction in motor adaptation: brain structural correlates and the role of explicit memory.
Not available
S-EPMC7181181 | biostudies-literature
UnknownFluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery.
Not available
S-EPMC10163929 | biostudies-literature
UnknownAssociations of Neighborhood Opportunity and Social Vulnerability With Trajectories of Childhood Body Mass Index and Obesity Among US Children.
Not available
S-EPMC9857328 | biostudies-literature
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