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ProteomicsMDR1 Drug Efflux Pump Promotes Acquired and Intrinsic Resistance to Protein Degraders in Cancer Cells
PROTACs (Proteolysis-Targeting Chimeras) represent a revolutionary new class of drugs that selectively degrade proteins of interest from cells. PROTACs targeting oncogenes are avidly being explored for cancer therapies, with several currently in clinical trials. Drug resistance represents a signif...
ORGANISM(S): Homo sapiens (Human) 
2022-10-06 | PXD029233 | Pride
Mdr1 Degrader Cancer Protac Drug resistance Abcb1 
TranscriptomicsTranscription profiling of human TK6 cells transduced with an oncoretrovirus expressing MDR1 (TK6MDR1) was vs untransduced TK6 cells and to TK6 cell transduced with an oncoretrovirus expressing the Neomycin resistance gene (TK6neo)
Gene expression of TK6 cells transduced with an oncoretrovirus expressing MDR1 (TK6MDR1) was compared to untransduced TK6 cells and to TK6 cell transduced with an oncoretrovirus expressing the Neomycin resistance gene (TK6neo). Two biological replicates of each were generated and the expression prof...
ORGANISM(S): Homo sapiens 
2005-09-15 | E-MEXP-428 | biostudies-arrayexpress
GenomicsASCL2 drives sorafenib resistance through FSAN-mediated MDR1 palmitoylation
ASCL2 drives sorafenib resistance through FSAN-mediated MDR1 palmitoylation
PRJNA1447465 | ENA
GenomicsPhysiologic expression and function of the MDR1 transporter in cytotoxic T lymphocytes
Physiologic expression and function of the MDR1 transporter in cytotoxic T lymphocytes
PRJNA599077 | ENA
TranscriptomicsExpression profiling of MDR1+ and MDR1- human memory T cells from the blood and clinically-inflamed gut tissue
The aim of this study was to characterize the transcriptional signature of MDR1+ human memory T cells isolated from clinically inflamed gut tissue, and compare it to local MDR1- memory T cells Human mononuclear cells were isolated from the peripheral blood of a healthy adult donor (Ficol density cen...
ORGANISM(S): Homo sapiens 
2013-12-17 | E-GEOD-49702 | biostudies-arrayexpress
TranscriptomicsExpression profiling of MDR1+ and MDR1- human memory T cells from the blood and clinically-inflamed gut tissue
The aim of this study was to characterize the transcriptional signature of MDR1+ human memory T cells isolated from clinically inflamed gut tissue, and compare it to local MDR1- memory T cells
ORGANISM(S): Homo sapiens 
2013-12-17 | GSE49702 | GEO
GenomicsscRNA-seq analyses on Thy1.1+Thy1.2+ MDR1-sufficient and Thy1.1+Thy1.2- MDR1-deficient P14 CD8+ T cells from ten congenically-transferred and LCMV-infected wild type B6 mice at day 8 post-infection
scRNA-seq analyses on Thy1.1+Thy1.2+ MDR1-sufficient and Thy1.1+Thy1.2- MDR1-deficient P14 CD8+ T cells from ten congenically-transferred and LCMV-infected wild type B6 mice at day 8 post-infection
PRJNA599079 | ENA
GenomicsThe Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids
The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids
PRJNA600300 | ENA
TranscriptomicsPhysiologic expression and function of the MDR1 transporter in cytotoxic T lymphocytes
Multidrug resistance (MDR)-1 acts as a chemotherapeutic drug efflux pump in tumor cells, although its physiologic functions remain enigmatic. Using a recently-developed MDR1-knockin reporter allele (Abcb1aAME/+), we found that constitutive MDR1 expression amongst hematopoietic cells was observed mai...
ORGANISM(S): Mus musculus 
2020-02-27 | GSE143141 | GEO
GenomicsRNA-Seq of Day 6 in vitro generated cells with and without Mdr1 expression and Elacridar treatment
RNA-Seq of Day 6 in vitro generated cells with and without Mdr1 expression and Elacridar treatment
PRJNA599080 | ENA
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