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ProteomicsTargeted AURKA degradation: Towards new therapeutic agents for neuroblastoma
Aurora kinase A (AURKA) is a well-established target in neuroblastoma (NB) due to both its catalytic functions during mitosis and its kinase-independent functions, including stabilization of the key oncoprotein MYCN. We present a structure-activity relationship (SAR) study of MK-5108-derived PROTACs...
ORGANISM(S): Homo sapiens (Human) 
2023-02-27 | PXD040391 | Pride
Aurka  mycn  neuroblastoma  protac  targeted protein degradation 
ProteomicsTargeted AURKA degradation: Towards new therapeutic agents for neuroblastoma
Aurora kinase A (AURKA) is a well-established target in neuroblastoma (NB) due to both its catalytic functions during mitosis and its kinase-independent functions, including stabilization of the key oncoprotein MYCN. We present a structure-activity relationship (SAR) study of MK-5108-derived PROTACs...
ORGANISM(S): Homo sapiens (Human) 
2023-02-27 | PXD040389 | Pride
Aurka  mycn  neuroblastoma  protac  targeted protein degradation 
TranscriptomicsTranscription profiling by array of human T24 bladder cancer cells in response to hypericin-mediated photodynamic therapy in the absence or presence of the p38 MAPK inhibitor PD169316
Study of the gene expression of T24 bladder cancer cells in response to hypericin-mediated photodynamic therapy in the absence or presence of the p38 MAPK inhibitor PD169316
ORGANISM(S): Homo sapiens 
2007-10-01 | E-MEXP-1220 | biostudies-arrayexpress
UnknownEarly and late effects of pharmacological ALK inhibition on the neuroblastoma transcriptome.
Not available
S-EPMC5739776 | biostudies-literature
TranscriptomicsTranscription profiling of the radicle and micropylar endosperm cap of Lepidium seeds during germination in control medium
An experiment was performed to compare global transcription patterns in three tissues of Lepidium sativum seeds at different times during imbibition leading up to, but not including, radicle protrusion from the seed (e.g. germination). RNA extractions from the three tissues were hybridised to CATMA ...
ORGANISM(S): Lepidium sativum 
2010-06-23 | E-TABM-745 | biostudies-arrayexpress
GenomicsH3K27ac ChIP-Seq in LOUCY
H3K27ac ChIP-Seq data of the T-ALL cell line LOUCY was obtained to find active regions in the genome and to correlate that with expression profiling of lncRNAs in the LOUCY cell line. ChIP-sequencing data was generated for H3K27ac in the T-ALL cell line LOUCY.
ORGANISM(S): Homo sapiens 
2016-05-17 | E-GEOD-74311 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of the GSI treatment of the CUTLL1 cell line
Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable complexity of oncogenic and loss-of-function mutations. Amongst this plethora of genetic changes, NOTCH1 activating mutations stand out as the most frequently occurring genetic defect, identified in more than 50% of T...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-61999 | biostudies-arrayexpress
UnknownIn silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors.
Not available
S-EPMC6269481 | biostudies-literature
TranscriptomicsComparative genomic hybridization of DNA from Lepidium sativum and Arabidopsis thaliana
An experiment was performed to compare genomic DNA from Lepidium sativum and Arabidopsis thaliana, on microarrays spotted with CATMA Arabidopsis GSTs
ORGANISM(S): Lepidium sativum 
2010-10-02 | E-TABM-744 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of the radicle and micropylar endosperm cap of Lepidium seeds during germination in ABA
An experiment was performed to compare global transcription patterns in two tissues of Lepidium sativum seeds at different times during imbibition leading up to, but not including, radicle protrusion from the seed (e.g. germination). RNA extractions from the two tissues were hybridised to CATMA Arab...
ORGANISM(S): Lepidium sativum 
2010-10-02 | E-TABM-743 | biostudies-arrayexpress
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