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GenomicsRNAseq experiment to identify differentially expressed genes in dvl/rtfl mutants and DVL overexpresion lines in inflorescence apices of Arabidopsis thaliana
RNAseq experiment to identify differentially expressed genes in dvl/rtfl mutants and DVL overexpresion lines in inflorescence apices of Arabidopsis thaliana
PRJNA1017400 | ENA
ProteomicsHuwe1-mediated ubiquitylation of Dvl defines a novel negative feedback loop in the Wnt signaling pathway
Wnt signaling plays a central role in development, adult tissue homeostasis and cancer. Several steps in the canonical Wnt/b-catenin signaling cascade are regulated by ubiquitylation, a protein modification that influences the stability, subcellular localization or protein-protein interactions of ta...
ORGANISM(S): Mus musculus (Mouse) 
2014-05-28 | PXD000781 | Pride
Dvl Wnt signaling Ubiquitylation 
TranscriptomicsTranscription profiling of Arabidopsis plants overexpressing a member of the DEVIL gene family.
The DEVIL (DVL) family is a plant-specific family of genes that encode predicted small polypeptides (Wen, et al., 2004; Narita, et al., 2004). Overexpression of DVL family members in Arabidopsis results in pleiotropic developmental phenotypes including shortened stature, rounded rosette leaves, clus...
ORGANISM(S): Arabidopsis thaliana 
2009-08-09 | E-GEOD-8975 | biostudies-arrayexpress
TranscriptomicsRNAseq experiment to identify differentially expressed genes in dvl/rtfl mutants and DVL overexpresion lines in inflorescence apices of Arabidopsis thaliana
The lack of visible phenotypes of multiple dvl/rtfl mutants prompted us to compare the transcriptomic signatures of inflorescence apices of wildtype and mutant combinations (specifically dvl1 dvl8 dvl11 rtfl11 dvl19 and dvl8 dvl11 rtfl9 rtfl11 dvl19), as well as dvl1-D mutant, where DVL1 is overexpr...
ORGANISM(S): Arabidopsis thaliana 
2023-09-19 | GSE243205 | GEO
TranscriptomicsNucleoredoxin is required for the maintenance of Wnt/β-catenin signaling in mice embryo
We previously showed that nucleoredoxin (NRX) suppresses Wnt/β-catenin signaling through its binding to Dishevelled (Dvl) (Nat Cell Biol 8, 501-508 (2006)). To clarify the in vivo role of NRX in mammals, we here generate NRX gene-knockout mice (NRX-/- mice) by homologous recombination. NRX-/- mice ...
ORGANISM(S): Mus musculus 
2010-10-26 | E-GEOD-21954 | biostudies-arrayexpress
UnknownFOXKs promote Wnt/β-catenin signaling by translocating DVL into the nucleus.
Not available
S-EPMC4374128 | biostudies-literature
UnknownInhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein.
Not available
S-EPMC88806 | biostudies-literature
UnknownRegulation of phosphatidylinositol kinases and metabolism by Wnt3a and Dvl.
Not available
S-EPMC2755661 | biostudies-literature
ProteomicsMultisite phosphorylation of intrinsically disordered region of DVL
When WNT binds to its receptor Frizzled (FZD) to activate the signalling, Dishevelled (DVL), the central component of Wnt signalling, is phosphorylated by redundant Casein kinase 1 (CK1) isoforms ε or δ, to transduce the signal downstream. Although the basic principles of Wnt signal transduction are...
ORGANISM(S): Homo sapiens (Human) 
2026-04-07 | PXD063926 | Pride
Dishevelled Endogenous Phosphorylation 
TranscriptomicsThe exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development
Wingless (Wg)/Wnt signaling is conserved in all metazoan animals and plays critical roles in development. The Wg/Wnt morphogen reception is essential for signal activation, whose activity is mediated through the receptor complex and a scaffold protein Dishevelled (Dsh). We report here that the exon ...
ORGANISM(S): Drosophila melanogaster 
2016-08-19 | E-GEOD-81220 | biostudies-arrayexpress
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